
Role of non‑coding RNA intertwined with the Wnt/β‑catenin signaling pathway in endometrial cancer (Review)
- Authors:
- Yanpeng Tian
- Tianjiao Lai
- Zhongkang Li
- Meng Mao
- Yuxi Jin
- Yana Liu
- Ruixia Guo
-
Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China - Published online on: June 20, 2023 https://doi.org/10.3892/mmr.2023.13037
- Article Number: 150
-
Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
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Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI | |
Xia C, Dong X, Li H, Cao M, Sun D, He S, Yang F, Yan X, Zhang S, Li N and Chen W: Cancer statistics in China and United States, 2022: Profiles, trends, and determinants. Chin Med J (Engl). 135:584–590. 2022. View Article : Google Scholar : PubMed/NCBI | |
Yen TT, Wang TL, Fader AN, Shih IM and Gaillard S: Molecular classification and emerging targeted therapy in endometrial cancer. Int J Gynecol Pathol. 39:26–35. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, Zhou Z, Shu G and Yin G: Wnt/β-catenin signalling: Function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 7:32022. View Article : Google Scholar : PubMed/NCBI | |
Nusse R and Varmus HE: Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 31:99–109. 1982. View Article : Google Scholar : PubMed/NCBI | |
Yu F, Yu C, Li F, Zuo Y, Wang Y, Yao L, Wu C, Wang C and Ye L: Wnt/β-catenin signaling in cancers and targeted therapies. Signal Transduct Target Ther. 6:3072021. View Article : Google Scholar : PubMed/NCBI | |
McMellen A, Woodruff ER, Corr BR, Bitler BG and Moroney MR: Wnt signaling in gynecologic malignancies. Int J Mol Sci. 21:42722020. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Chen X, Ji YR, Zhu S, Bu FT, Du XS, Meng XM, Huang C and Li J: PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β-catenin signalling pathway. J Cell Mol Med. 24:7405–7416. 2020. View Article : Google Scholar : PubMed/NCBI | |
Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, et al: TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Nat Cell Biol. 20:1421–1433. 2018. View Article : Google Scholar : PubMed/NCBI | |
Parrish ML, Broaddus RR and Gladden AB: Mechanisms of mutant β-catenin in endometrial cancer progression. Front Oncol. 12:10093452022. View Article : Google Scholar : PubMed/NCBI | |
Ledinek Z, Sobocan M and Knez J: The Role of CTNNB1 in endometrial cancer. Dis Markers. 2022:14424412022. View Article : Google Scholar : PubMed/NCBI | |
Moroney MR, Woodruff E, Qamar L, Bradford AP, Wolsky R, Bitler BG and Corr BR: Inhibiting Wnt/beta-catenin in CTNNB1-mutated endometrial cancer. Mol Carcinog. 60:511–523. 2021. View Article : Google Scholar : PubMed/NCBI | |
Pijnenborg JM, Kisters N, van Engeland M, Dunselman GA, de Haan J, de Goeij AF and Groothuis PG: APC, beta-catenin, and E-cadherin and the development of recurrent endometrial carcinoma. Int J Gynecol Cancer. 14:947–956. 2004. View Article : Google Scholar : PubMed/NCBI | |
Moreno-Bueno G, Hardisson D, Sanchez C, Sarrio D, Cassia R, Garcia-Rostan G, Prat J, Guo M, Herman JG, Matias-Guiu X, et al: Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Oncogene. 21:7981–7990. 2002. View Article : Google Scholar : PubMed/NCBI | |
van der Zee M, Jia Y, Wang Y, Heijmans-Antonissen C, Ewing PC, Franken P, Demayo FJ, Lydon JP, Burger CW, Fodde R and Blok LJ: Alterations in Wnt-beta-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J Pathol. 230:48–58. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kasoha M, Dernektsi C, Seibold A, Bohle RM, Takacs Z, Ioan-Iulian I, Solomayer EF and Juhasz-Boss I: Crosstalk of estrogen receptors and Wnt/β-catenin signaling in endometrial cancer. J Cancer Res Clin Oncol. 146:315–327. 2020. View Article : Google Scholar : PubMed/NCBI | |
Chen JJ, Xiao ZJ, Meng X, Wang Y, Yu MK, Huang WQ, Sun X, Chen H, Duan YG, Jiang X, et al: MRP4 sustains Wnt/beta-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics. 9:5049–5064. 2019. View Article : Google Scholar : PubMed/NCBI | |
Matsui M and Corey DR: Non-coding RNAs as drug targets. Nat Rev Drug Discov. 16:167–179. 2017. View Article : Google Scholar : PubMed/NCBI | |
Fitzgerald JB, George J and Christenson LK: Non-coding RNA in ovarian development and disease. Adv Exp Med Biol. 886:79–93. 2016. View Article : Google Scholar : PubMed/NCBI | |
Anastasiadou E, Jacob LS and Slack FJ: Non-coding RNA networks in cancer. Nat Rev Cancer. 18:5–18. 2018. View Article : Google Scholar : PubMed/NCBI | |
Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Zhao X, Guo Z, Ma X, Song Y and Guo Y: Regulation of NEAT1/miR-214-3p on the growth, migration and invasion of endometrial carcinoma cells. Arch Gynecol Obstet. 295:1469–1475. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li Z, Wei D, Yang C, Sun H, Lu T and Kuang D: Overexpression of long noncoding RNA, NEAT1 promotes cell proliferation, invasion and migration in endometrial endometrioid adenocarcinoma. Biomed Pharmacother. 84:244–251. 2016. View Article : Google Scholar : PubMed/NCBI | |
Sun C, Li S, Zhang F, Xi Y, Wang L, Bi Y and Li D: Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway. Oncotarget. 7:51784–51814. 2016. View Article : Google Scholar : PubMed/NCBI | |
Lai T, Qiu H, Si L, Zhen Y, Chu D and Guo R: Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway. Cell Cycle. 21:1599–1618. 2022. View Article : Google Scholar : PubMed/NCBI | |
Zhou Y, Pan A, Zhang Y and Li X: Hsa_circ_0039569 facilitates the progression of endometrial carcinoma by targeting the miR-197/high mobility group protein A1 axis. Bioengineered. 13:4212–4225. 2022. View Article : Google Scholar : PubMed/NCBI | |
Yi H, Han Y and Li S: Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression. Front Oncol. 12:9854702022. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Yuan H and He T: Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling. Bioengineered. 13:4634–4645. 2022. View Article : Google Scholar : PubMed/NCBI | |
Gu X, Shi Y, Dong M, Jiang L, Yang J and Liu Z: Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer. Cell Death Dis. 12:8182021. View Article : Google Scholar : PubMed/NCBI | |
Adler PN, Krasnow RE and Liu J: Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levels. Curr Biol. 7:940–949. 1997. View Article : Google Scholar : PubMed/NCBI | |
Wolff T and Rubin GM: Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development. 125:1149–1159. 1998. View Article : Google Scholar : PubMed/NCBI | |
Theisen H, Purcell J, Bennett M, Kansagara D, Syed A and Marsh JL: dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development. 120:347–360. 1994. View Article : Google Scholar : PubMed/NCBI | |
Gubb D, Green C, Huen D, Coulson D, Johnson G, Tree D, Collier S and Roote J: The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Genes Dev. 13:2315–2327. 1999. View Article : Google Scholar : PubMed/NCBI | |
Taciak B, Pruszynska I, Kiraga L, Bialasek M and Krol M: Wnt signaling pathway in development and cancer. J Physiol Pharmacol. 69((2))2018.PubMed/NCBI | |
Humphries AC and Mlodzik M: From instruction to output: Wnt/PCP signaling in development and cancer. Curr Opin Cell Biol. 51:110–116. 2018. View Article : Google Scholar : PubMed/NCBI | |
Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, Mcmahon AP, Willert K, Okada Y, et al: A Wnt5 activity asymmetry and intercellular signaling via PCP proteins polarize node cells for left-right symmetry breaking. Dev Cell. 40:439–452.e4. 2017. View Article : Google Scholar : PubMed/NCBI | |
Katoh M: WNT/PCP signaling pathway and human cancer (review). Oncol Rep. 14:1583–1588. 2005.PubMed/NCBI | |
Simons M and Mlodzik M: Planar cell polarity signaling: From fly development to human disease. Annu Rev Genet. 42:517–540. 2008. View Article : Google Scholar : PubMed/NCBI | |
Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, et al: Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol. 13:1129–1133. 2003. View Article : Google Scholar : PubMed/NCBI | |
Simons M and Walz G: Polycystic kidney disease: Cell division without a c(l)ue? Kidney Int. 70:854–864. 2006. View Article : Google Scholar : PubMed/NCBI | |
Garriock RJ, D'Agostino SL, Pilcher KC and Krieg PA: Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Dev Biol. 279:179–192. 2005. View Article : Google Scholar : PubMed/NCBI | |
Pennekamp P, Menchen T, Dworniczak B and Hamada H: Situs inversus and ciliary abnormalities: 20 years later, what is the connection? Cilia. 4:12015. View Article : Google Scholar : PubMed/NCBI | |
Hong CF, Chen WY and Wu CW: Upregulation of Wnt signaling under hypoxia promotes lung cancer progression. Oncol Rep. 38:1706–1714. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, Yasui W and Kikuchi A: Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res. 66:10439–10448. 2006. View Article : Google Scholar : PubMed/NCBI | |
Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M and Wrana JL: Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell. 151:1542–1556. 2012. View Article : Google Scholar : PubMed/NCBI | |
Daulat AM, Bertucci F, Audebert S, Serge A, Finetti P, Josselin E, Castellano R, Birnbaum D, Angers S and Borg JP: PRICKLE1 Contributes to Cancer Cell Dissemination through Its Interaction with mTORC2. Dev Cell. 37:311–325. 2016. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Luga V, Armitage SK, Musiol M, Won A, Yip CM, Plotnikov SV and Wrana JL: A lateral signalling pathway coordinates shape volatility during cell migration. Nat Commun. 7:117142016. View Article : Google Scholar : PubMed/NCBI | |
Yang N, Chen H, Huang Y, Song X, Yang P, Zhang S, Yan W, Li N and Feng Z: The role and significance of wnt5a in regulating epithelial-mesenchymal transition in endometrioid adenocarcinoma. Cancer Manag Res. 13:6527–6535. 2021. View Article : Google Scholar : PubMed/NCBI | |
Ma J, Kong FF, Yang D, Yang H, Wang C, Cong R and Ma XX: lncRNA MIR210HG promotes the progression of endometrial cancer by sponging miR-337-3p/137 via the HMGA2-TGF-β/Wnt pathway. Mol Ther Nucleic Acids. 24:905–922. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wasniewski T, Kiezun J, Krazinski BE, Kowalczyk AE, Szostak B, Wierzbicki PM and Kiewisz J: WNT5A gene and protein expression in endometrial cancer. Folia Histochem Cytobiol. 57:84–93. 2019. View Article : Google Scholar : PubMed/NCBI | |
Mikels A, Minami Y and Nusse R: Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem. 284:30167–30176. 2009. View Article : Google Scholar : PubMed/NCBI | |
Nakano K, Chihara Y, Kobayashi S, Iwanaga M, Utsunomiya A, Watanabe T and Uchimaru K: Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL) cells. Sci Rep. 11:41142021. View Article : Google Scholar : PubMed/NCBI | |
Pukrop T, Klemm F, Hagemann T, Gradl D, Schulz M, Siemes S, Trumper L and Binder C: Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci USA. 103:5454–5459. 2006. View Article : Google Scholar : PubMed/NCBI | |
Wang Q, Symes AJ, Kane CA, Freeman A, Nariculam J, Munson P, Thrasivoulou C, Masters JR and Ahmed A: A novel role for Wnt/Ca2+ signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. PLoS One. 5:e104562010. View Article : Google Scholar : PubMed/NCBI | |
Macleod RJ, Hayes M and Pacheco I: Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am J Physiol Gastrointest Liver Physiol. 293:G403–G411. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kremenevskaja N, von Wasielewski R, Rao AS, Schofl C, Andersson T and Brabant G: Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene. 24:2144–2154. 2005. View Article : Google Scholar : PubMed/NCBI | |
Zmarzly N, Hermyt E, Kruszniewska-Rajs C, Gola J, Witek A, Mazurek U, Ostenda A and Boron D: Expression Profile of EMT-related Genes and miRNAs involved in signal transduction via the Wnt pathway and cadherins in endometrial cancer. Curr Pharm Biotechnol. 22:1663–1671. 2021. View Article : Google Scholar : PubMed/NCBI | |
Tewari D, Bawari S, Sharma S, Deliberto LK and Bishayee A: Targeting the crosstalk between canonical Wnt/β-catenin and inflammatory signaling cascades: A novel strategy for cancer prevention and therapy. Pharmacol Ther. 227:1078762021. View Article : Google Scholar : PubMed/NCBI | |
Kurnit KC, Kim GN, Fellman BM, Urbauer DL, Mills GB, Zhang W and Broaddus RR: CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence. Mod Pathol. 30:1032–1041. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ruz-Caracuel I, Lopez-Janeiro A, Heredia-Soto V, Ramon-Patino JL, Yebenes L, Berjon A, Hernandez A, Gallego A, Ruiz P, Redondo A, et al: Clinicopathological features and prognostic significance of CTNNB1 mutation in low-grade, early-stage endometrial endometrioid carcinoma. Virchows Arch. 479:1167–1176. 2021. View Article : Google Scholar : PubMed/NCBI | |
Costigan DC, Dong F, Nucci MR and Howitt BE: Clinicopathologic and immunohistochemical correlates of CTNNB1 mutated endometrial endometrioid carcinoma. Int J Gynecol Pathol. 39:119–127. 2020. View Article : Google Scholar : PubMed/NCBI | |
Goad J, Ko YA, Kumar M, Jamaluddin MFB and Tanwar PS: Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/β-catenin signalling. Carcinogenesis. 39:1105–1116. 2018. View Article : Google Scholar : PubMed/NCBI | |
Valenta T, Hausmann G and Basler K: The many faces and functions of β-catenin. EMBO J. 31:2714–2736. 2012. View Article : Google Scholar : PubMed/NCBI | |
Heuberger J and Birchmeier W: Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol. 2:a29152010. View Article : Google Scholar : PubMed/NCBI | |
Barrallo-Gimeno A and Nieto MA: The Snail genes as inducers of cell movement and survival: Implications in development and cancer. Development. 132:3151–3161. 2005. View Article : Google Scholar : PubMed/NCBI | |
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P and Ben-Ze'ev A: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol. 163:847–857. 2003. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y and Wang X: Targeting the Wnt/β-catenin signaling pathway in cancer. J Hematol Oncol. 13:1652020. View Article : Google Scholar : PubMed/NCBI | |
Krishnamurthy N and Kurzrock R: Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors. Cancer Treat Rev. 62:50–60. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhou Y, Zhu Y, Xie Y and Ma X: The role of long Non-coding RNAs in immunotherapy resistance. Front Oncol. 9:12922019. View Article : Google Scholar : PubMed/NCBI | |
Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI | |
Heuston EF, Lemon KT and Arceci RJ: The beginning of the road for Non-Coding RNAs in normal hematopoiesis and hematologic malignancies. Front Genet. 2:942011. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Shen S, Yang Z, Kong X, Liu F and Zhen Z: Coding and Non-coding RNAs: Molecular basis of forest-insect outbreaks. Front Cell Dev Biol. 8:3692020. View Article : Google Scholar : PubMed/NCBI | |
Mendell JT: Targeting a long Noncoding RNA in breast cancer. N Engl J Med. 374:2287–2289. 2016. View Article : Google Scholar : PubMed/NCBI | |
Karimzadeh MR, Pourdavoud P, Ehtesham N, Qadbeigi M, Asl MM, Alani B, Mosallaei M and Pakzad B: Regulation of DNA methylation machinery by epi-miRNAs in human cancer: Emerging new targets in cancer therapy. Cancer Gene Ther. 28:157–174. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li C, Liu H, Wei R, Liu Z, Chen H, Guan X, Zhao Z, Wang X and Jiang Z: LncRNA EGOT/miR-211-5p affected radiosensitivity of rectal cancer by competitively regulating ErbB4. Onco Targets Ther. 14:2867–2878. 2021. View Article : Google Scholar : PubMed/NCBI | |
Hong BS, Ryu HS, Kim N, Kim J, Lee E, Moon H, Kim KH, Jin MS, Kwon NH, Kim S, et al: Tumor Suppressor miRNA-204-5p Regulates Growth, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer. Cancer Res. 79:1520–1534. 2019. View Article : Google Scholar : PubMed/NCBI | |
Huang Y, Liu G, Ma H, Tian Y, Huang C, Liu F, Jia Y and Jiang D: Plasma lncRNA FEZF1-AS1 as a potential biomarker for diagnosis of non-small-cell lung carcinoma. Medicine (Baltimore). 99:e210192020. View Article : Google Scholar : PubMed/NCBI | |
Liao Y, Cao W, Zhang K, Zhou Y, Xu X, Zhao X, Yang X, Wang J, Zhao S, Zhang S, et al: Bioinformatic and integrated analysis identifies an lncRNA-miRNA-mRNA interaction mechanism in gastric adenocarcinoma. Genes Genomics. 43:613–622. 2021. View Article : Google Scholar : PubMed/NCBI | |
Piergentili R, Zaami S, Cavaliere AF, Signore F, Scambia G, Mattei A, Marinelli E, Gulia C and Perelli F: Non-Coding RNAs as prognostic markers for endometrial cancer. Int J Mol Sci. 22:31512021. View Article : Google Scholar : PubMed/NCBI | |
Liu D, Song Z, Wang X and Ouyang L: Ubiquitin C-Terminal Hydrolase L5 (UCHL5) accelerates the growth of endometrial cancer via activating the Wnt/β-catenin signaling pathway. Front Oncol. 10:8652020. View Article : Google Scholar : PubMed/NCBI | |
Fatima I, Barman S, Rai R, Thiel KWW and Chandra V: Targeting Wnt signaling in endometrial cancer. Cancers (Basel). 13:23512021. View Article : Google Scholar : PubMed/NCBI | |
Wang ZM, Wan XH, Sang GY, Zhao JD, Zhu QY and Wang DM: miR-15a-5p suppresses endometrial cancer cell growth via Wnt/β-catenin signaling pathway by inhibiting WNT3A. Eur Rev Med Pharmacol Sci. 21:4810–4818. 2017.PubMed/NCBI | |
Li Y, Liu J, Piao J, Ou J and Zhu X: Circ_0109046 promotes the malignancy of endometrial carcinoma cells through the microRNA-105/SOX9/Wnt/β-catenin axis. IUBMB Life. 73:159–176. 2021. View Article : Google Scholar : PubMed/NCBI | |
Shang JC, Yu GZ, Ji ZW, Wang XQ and Xia L: MiR-105 inhibits gastric cancer cells metastasis, epithelial-mesenchymal transition by targeting SOX9. Eur Rev Med Pharmacol Sci. 23:6160–6169. 2019.PubMed/NCBI | |
Xu H, Gong Z, Shen Y, Fang Y and Zhong S: Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Epigenomics. 10:187–197. 2018. View Article : Google Scholar : PubMed/NCBI | |
Shen Q, He T and Yuan H: Hsa_circ_0002577 promotes endometrial carcinoma progression via regulating miR-197/CTNND1 axis and activating Wnt/β-catenin pathway. Cell Cycle. 18:1229–1240. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liu D, Qiu M, Jiang L and Liu K: Long Noncoding RNA HOXB-AS1 is upregulated in endometrial carcinoma and sponged miR-149-3p to Upregulate Wnt10b. Technol Cancer Res Treat. 19:15330338209674622020. View Article : Google Scholar : PubMed/NCBI | |
Wang H and Xie Y: BRD7-Mediated miR-3148 inhibits progression of cervical cancer by targeting Wnt3a/β-catenin pathway. Reprod Sci. 27:877–887. 2020. View Article : Google Scholar : PubMed/NCBI | |
Shen G, Gao Q, Liu F, Zhang Y, Dai M, Zhao T, Cheng M, Xu T, Jin P, Yin W, et al: The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab. Biochem Biophys Res Commun. 526:685–691. 2020. View Article : Google Scholar : PubMed/NCBI | |
Jiang H, Li Y, Li J, Zhang X, Niu G, Chen S and Yao S: Long noncoding RNA LSINCT5 promotes endometrial carcinoma cell proliferation, cycle, and invasion by promoting the Wnt/β-catenin signaling pathway via HMGA2. Ther Adv Med Oncol. 11:17588359198746492019. View Article : Google Scholar : PubMed/NCBI | |
Park SA, Kim LK, Kim YT, Heo TH and Kim HJ: Long non-coding RNA steroid receptor activator promotes the progression of endometrial cancer via Wnt/β-catenin signaling pathway. Int J Biol Sci. 16:99–115. 2020. View Article : Google Scholar : PubMed/NCBI | |
Wang H, Yang Q, Li J, Chen W, Jin X and Wang Y: MicroRNA-15a-5p inhibits endometrial carcinoma proliferation, invasion and migration via downregulation of VEGFA and inhibition of the Wnt/β-catenin signaling pathway. Oncol Lett. 21:3102021. View Article : Google Scholar : PubMed/NCBI | |
Chen P, Xing T, Wang Q, Liu A, Liu H, Hu Y, Ji Y, Song Y and Wang D: MicroRNA-202 inhibits cell migration and invasion through targeting FGF2 and inactivating Wnt/beta-catenin signaling in endometrial carcinoma. Biosci Rep. 39:BSR201906802019. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Sun D, Gao J, Shi Z, Chi P, Meng Y, Zou C and Wang Y: MicroRNA-373 promotes the development of endometrial cancer by targeting LATS2 and activating the Wnt/beta-Catenin pathway. J Cell Biochem. 120:8611–8618. 2019. View Article : Google Scholar : PubMed/NCBI | |
Sun X, Dongol S, Qiu C, Xu Y, Sun C, Zhang Z, Yang X, Zhang Q and Kong B: miR-652 promotes tumor proliferation and metastasis by targeting RORA in endometrial cancer. Mol Cancer Res. 16:1927–1939. 2018. View Article : Google Scholar : PubMed/NCBI | |
Huang X, Zhong R, He X, Deng Q, Peng X, Li J and Luo X: Investigations on the mechanism of progesterone in inhibiting endometrial cancer cell cycle and viability via regulation of long noncoding RNA NEAT1/microRNA-146b-5p mediated Wnt/β-catenin signaling. IUBMB Life. 71:223–234. 2019. View Article : Google Scholar : PubMed/NCBI | |
Jung YS and Park JI: Wnt signaling in cancer: Therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex. Exp Mol Med. 52:183–191. 2020. View Article : Google Scholar : PubMed/NCBI | |
Werner J, Boonekamp KE, Zhan T and Boutros M: The roles of secreted Wnt ligands in cancer. Int J Mol Sci. 24:53492023. View Article : Google Scholar : PubMed/NCBI | |
Doo DW, Meza-Perez S, Londono AI, Goldsberry WN, Katre AA, Boone JD, Moore DJ, Hudson CT, Betella I, Mccaw TR, et al: Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer. Ther Adv Med Oncol. 12:17588359209137982020. View Article : Google Scholar : PubMed/NCBI | |
Rodon J, Argiles G, Connolly RM, Vaishampayan U, de Jonge M, Garralda E, Giannakis M, Smith DC, Dobson JR, McLaughlin ME, et al: Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours. Br J Cancer. 125:28–37. 2021. View Article : Google Scholar : PubMed/NCBI | |
Tabernero J, Van Cutsem E, Garralda E, Tai D, De Braud F, Geva R, van Bussel MTJ, Fiorella Dotti K, Elez E, de Miguel MJ, et al: A Phase Ib/II Study of WNT974 + Encorafenib + cetuximab in patients with BRAF V600E-Mutant KRAS wild-type metastatic colorectal cancer. Oncologist. 28:230–238. 2023. View Article : Google Scholar : PubMed/NCBI | |
Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, et al: Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene. 35:2197–2207. 2016. View Article : Google Scholar : PubMed/NCBI | |
He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, Mccormick F and Jablons DM: A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia. 6:7–14. 2004. View Article : Google Scholar : PubMed/NCBI | |
Davis SL, Cardin DB, Shahda S, Lenz HJ, Dotan E, O'Neil BH, Kapoun AM, Stagg RJ, Berlin J, Messersmith WA and Cohen SJ: A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer. Invest New Drugs. 38:821–830. 2020. View Article : Google Scholar : PubMed/NCBI | |
Diamond JR, Becerra C, Richards D, Mita A, Osborne C, O'Shaughnessy J, Zhang C, Henner R, Kapoun AM, Xu L, et al: Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer. Breast Cancer Res Treat. 184:53–62. 2020. View Article : Google Scholar : PubMed/NCBI | |
Smith DC, Rosen LS, Chugh R, Goldman JW, Xu L, Kapoun A, Brachmann RK, Dupont J, Stagg RJ, Tolcher AW, et al: First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5; anti-Frizzled) targeting the WNT pathway in a phase I study for patients with advanced solid tumors. J Clin Oncol. 31 (Suppl 15):25402013. View Article : Google Scholar | |
Le PN, Mcdermott JD and Jimeno A: Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28. Pharmacol Ther. 146:1–11. 2015. View Article : Google Scholar : PubMed/NCBI | |
Fischer MM, Cancilla B, Yeung VP, Cattaruzza F, Chartier C, Murriel CL, Cain J, Tam R, Cheng CY, Evans JW, et al: WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death. Sci Adv. 3:e17000902017. View Article : Google Scholar : PubMed/NCBI | |
Jimeno A, Gordon M, Chugh R, Messersmith W, Mendelson D, Dupont J, Stagg R, Kapoun AM, Xu L, Uttamsingh S, et al: A First-in-Human Phase I study of the anticancer stem cell agent ipafricept (OMP-54F28), a decoy receptor for Wnt ligands, in patients with advanced solid tumors. Clin Cancer Res. 23:7490–7497. 2017. View Article : Google Scholar : PubMed/NCBI | |
Moore KN, Gunderson CC, Sabbatini P, McMeekin DS, Mantia-Smaldone G, Burger RA, Morgan MA, Kapoun AM, Brachmann RK, Stagg R, et al: A phase 1b dose escalation study of ipafricept (OMP54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer. Gynecol Oncol. 154:294–301. 2019. View Article : Google Scholar : PubMed/NCBI | |
Dotan E, Cardin DB, Lenz HJ, Messersmith W, O'Neil B, Cohen SJ, Denlinger CS, Shahda S, Astsaturov I, Kapoun AM, et al: Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in patients with previously untreated stage IV pancreatic cancer. Clin Cancer Res. 26:5348–5357. 2020. View Article : Google Scholar : PubMed/NCBI | |
Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M, Moon RT, Teo JL, Kim HY, Moon SH, et al: A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci USA. 101:12682–12687. 2004. View Article : Google Scholar : PubMed/NCBI | |
Pozzi S, Fulciniti M, Yan H, Vallet S, Eda H, Patel K, Santo L, Cirstea D, Hideshima T, Schirtzinge L, et al: In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma. Bone. 53:487–496. 2013. View Article : Google Scholar : PubMed/NCBI | |
Arend R, Dholakia J, Castro C, Matulonis U, Hamilton E, Jackson CG, Lybarger K, Goodman HM, Duska LR, Mahdi H, et al: DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma. Gynecol Oncol. 172:82–91. 2023. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Hanifi-Moghaddam P, Hanekamp EE, Kloosterboer HJ, Franken P, Veldscholte J, van Doorn HC, Ewing PC, Kim JJ, Grootegoed JA, et al: Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer. Clin Cancer Res. 15:5784–5793. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yahata T, Fujita K, Aoki Y and Tanaka K: Long-term conservative therapy for endometrial adenocarcinoma in young women. Hum Reprod. 21:1070–1075. 2006. View Article : Google Scholar : PubMed/NCBI | |
Arend RC, Londono-Joshi AI, Samant RS, Li Y, Conner M, Hidalgo B, Alvarez RD, Landen CN, Straughn JM and Buchsbaum DJ: Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer. Gynecol Oncol. 134:112–120. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kusunoki S, Kato K, Tabu K, Inagaki T, Okabe H, Kaneda H, Suga S, Terao Y, Taga T and Takeda S: The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells. Gynecol Oncol. 129:598–605. 2013. View Article : Google Scholar : PubMed/NCBI | |
Feng W, Yang CX, Zhang L, Fang Y and Yan M: Curcumin promotes the apoptosis of human endometrial carcinoma cells by downregulating the expression of androgen receptor through Wnt signal pathway. Eur J Gynaecol Oncol. 35:718–723. 2014.PubMed/NCBI | |
Wang WT, Han C, Sun YM, Chen TQ and Chen YQ: Noncoding RNAs in cancer therapy resistance and targeted drug development. J Hematol Oncol. 12:552019. View Article : Google Scholar : PubMed/NCBI | |
Kelnar K, Peltier HJ, Leatherbury N, Stoudemire J and Bader AG: Quantification of therapeutic miRNA mimics in whole blood from nonhuman primates. Anal Chem. 86:1534–1542. 2014. View Article : Google Scholar : PubMed/NCBI |