Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease

Alomair,Amar; Alamri,Abdullah; Shaik,Jilani; Aljafari,Salman; Ba Abdullah,Mohammed; Alanazi,Mohammad

doi:10.3892/mmr.2024.13177

Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease

Authors:
- Amar Alomair
- Abdullah Alamri
- Jilani Shaik
- Salman Aljafari
- Mohammed Ba Abdullah
- Mohammad Alanazi
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Affiliations: Genome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Kingdom of Saudi Arabia, Department of Biological Sciences, College of Science, King Faisal University, Al‑Ahsa 31982, Kingdom of Saudi Arabia
Published online on: February 7, 2024 https://doi.org/10.3892/mmr.2024.13177
Article Number: 53
Copyright: © Alomair et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and multiple single‑nucleotide polymorphisms of DNA repair genes have been found to be associated with CVD. The aim of the present study was to assess the effects of the genetic variants of RAD51 recombinase (RAD51) and 8‑oxoguanine DNA glycosylase (OGG1) on CVD through genotyping and statistical analysis. Regardless of whether there is a significant association or not, the genotyping data on these two polymorphisms are valuable, because there is limited availability of it in certain populations. A total of 240 blood samples were analyzed and genotyped using TaqMan genotyping; 120 were obtained from cases with a history of CVD, and 120 from cases with no history of CVD. A questionnaire was administered to gather information on age, demographics, sex and clinical features, and confirmation was carried out using medical records. The results of the present study confirmed that the polymorphism rs1052133 in OGG1 had no significant association with CVD. On the other hand, the polymorphism rs1801321 in RAD51 exhibited a significant association with CVD. Collectively, the results of the present study revealed that the polymorphism rs1801321 in RAD51 exhibited a significant association with CVD, however a larger sample size to confirm the present findings, may allow for the early identification of CVD and may aid in the decision‑making process concerning treatments for CVD.

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