Open Access

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

  • Authors:
    • Lei Cheng
    • Lijuan Guo
    • Teng Zou
    • Yisong Yang
    • Ran Tao
    • Shuangping Liu
  • View Affiliations

  • Published online on: April 3, 2024     https://doi.org/10.3892/mmr.2024.13213
  • Article Number: 89
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatitis B X‑interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post‑transcription and post‑translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.
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June-2024
Volume 29 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Cheng L, Guo L, Zou T, Yang Y, Tao R and Liu S: Research progress on oncoprotein hepatitis B X‑interacting protein (Review). Mol Med Rep 29: 89, 2024.
APA
Cheng, L., Guo, L., Zou, T., Yang, Y., Tao, R., & Liu, S. (2024). Research progress on oncoprotein hepatitis B X‑interacting protein (Review). Molecular Medicine Reports, 29, 89. https://doi.org/10.3892/mmr.2024.13213
MLA
Cheng, L., Guo, L., Zou, T., Yang, Y., Tao, R., Liu, S."Research progress on oncoprotein hepatitis B X‑interacting protein (Review)". Molecular Medicine Reports 29.6 (2024): 89.
Chicago
Cheng, L., Guo, L., Zou, T., Yang, Y., Tao, R., Liu, S."Research progress on oncoprotein hepatitis B X‑interacting protein (Review)". Molecular Medicine Reports 29, no. 6 (2024): 89. https://doi.org/10.3892/mmr.2024.13213