Open Access

TGF‑β/Smad signaling in chronic kidney disease: Exploring post‑translational regulatory perspectives (Review)

  • Authors:
    • Jianchun Li
    • Yuanxia Zou
    • Jiraporn Kantapan
    • Hongwei Su
    • Li Wang
    • Nathupakorn Dechsupa
  • View Affiliations

  • Published online on: June 18, 2024     https://doi.org/10.3892/mmr.2024.13267
  • Article Number: 143
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The TGF‑β/Smad signaling pathway plays a pivotal role in the onset of glomerular and tubulointerstitial fibrosis in chronic kidney disease (CKD). The present review delves into the intricate post‑translational modulation of this pathway and its implications in CKD. Specifically, the impact of the TGF‑β/Smad pathway on various biological processes was investigated, encompassing not only renal tubular epithelial cell apoptosis, inflammation, myofibroblast activation and cellular aging, but also its role in autophagy. Various post‑translational modifications (PTMs), including phosphorylation and ubiquitination, play a crucial role in modulating the intensity and persistence of the TGF‑β/Smad signaling pathway. They also dictate the functionality, stability and interactions of the TGF‑β/Smad components. The present review sheds light on recent findings regarding the impact of PTMs on TGF‑β receptors and Smads within the CKD landscape. In summary, a deeper insight into the post‑translational intricacies of TGF‑β/Smad signaling offers avenues for innovative therapeutic interventions to mitigate CKD progression. Ongoing research in this domain holds the potential to unveil powerful antifibrotic treatments, aiming to preserve renal integrity and function in patients with CKD.
View Figures
View References

Related Articles

Journal Cover

August-2024
Volume 30 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Zou Y, Kantapan J, Su H, Wang L and Dechsupa N: TGF‑β/Smad signaling in chronic kidney disease: Exploring post‑translational regulatory perspectives (Review). Mol Med Rep 30: 143, 2024
APA
Li, J., Zou, Y., Kantapan, J., Su, H., Wang, L., & Dechsupa, N. (2024). TGF‑β/Smad signaling in chronic kidney disease: Exploring post‑translational regulatory perspectives (Review). Molecular Medicine Reports, 30, 143. https://doi.org/10.3892/mmr.2024.13267
MLA
Li, J., Zou, Y., Kantapan, J., Su, H., Wang, L., Dechsupa, N."TGF‑β/Smad signaling in chronic kidney disease: Exploring post‑translational regulatory perspectives (Review)". Molecular Medicine Reports 30.2 (2024): 143.
Chicago
Li, J., Zou, Y., Kantapan, J., Su, H., Wang, L., Dechsupa, N."TGF‑β/Smad signaling in chronic kidney disease: Exploring post‑translational regulatory perspectives (Review)". Molecular Medicine Reports 30, no. 2 (2024): 143. https://doi.org/10.3892/mmr.2024.13267