Open Access

Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)

  • Authors:
    • Zhuojian Qu
    • Yirui Lu
    • Yutong Ran
    • Donghua Xu
    • Zhiliang Guo
    • Min Cheng
  • View Affiliations

  • Published online on: August 6, 2024     https://doi.org/10.3892/mmr.2024.13300
  • Article Number: 176
  • Copyright: © Qu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chitinase‑3 like‑protein‑1 (CHI3L1), a glycoprotein belonging to the glycoside hydrolase family 18, binds to chitin; however, this protein lacks chitinase activity. Although CHI3L1 is not an enzyme capable of degrading chitin, it plays significant roles in abnormal glucose and lipid metabolism, indicating its involvement in metabolic disorders. In addition, CHI3L1 is considered a key player in inflammatory diseases, with clinical data suggesting its potential as a predictor of cardiovascular disease. CHI3L1 regulates the inflammatory response of various cell types, including macrophages, vascular smooth muscle cells and fibroblasts. In addition, CHI3L1 participates in vascular remodeling and fibrosis, contributing to the pathogenesis of cardiovascular disease. At present, research is focused on elucidating the role of CHI3L1 in cardiovascular disease. The present systematic review was conducted to comprehensively evaluate the effects of CHI3L1 on cardiovascular cells, and determine the potential implications in the occurrence and progression of cardiovascular disease. The present study may further the understanding of the involvement of CHI3L1 in cardiovascular pathology, demonstrating its potential as a therapeutic target or biomarker in the management of cardiovascular disease.
View Figures
View References

Related Articles

Journal Cover

October-2024
Volume 30 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Qu Z, Lu Y, Ran Y, Xu D, Guo Z and Cheng M: Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review). Mol Med Rep 30: 176, 2024.
APA
Qu, Z., Lu, Y., Ran, Y., Xu, D., Guo, Z., & Cheng, M. (2024). Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review). Molecular Medicine Reports, 30, 176. https://doi.org/10.3892/mmr.2024.13300
MLA
Qu, Z., Lu, Y., Ran, Y., Xu, D., Guo, Z., Cheng, M."Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)". Molecular Medicine Reports 30.4 (2024): 176.
Chicago
Qu, Z., Lu, Y., Ran, Y., Xu, D., Guo, Z., Cheng, M."Chitinase‑3 like‑protein‑1: A potential predictor of cardiovascular disease (Review)". Molecular Medicine Reports 30, no. 4 (2024): 176. https://doi.org/10.3892/mmr.2024.13300