Open Access

Role of pyruvate kinase M2 in regulating sepsis (Review)

  • Authors:
    • Yifei Hu
    • Jing Tang
    • Qiao Xu
    • Zenghui Fang
    • Rongqing Li
    • Mengxuan Yang
    • Jie Zhao
    • Xin Chen
  • View Affiliations

  • Published online on: August 16, 2024     https://doi.org/10.3892/mmr.2024.13309
  • Article Number: 185
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glycolysis occurs in all living organisms as a form of energy supply. Pyruvate kinase M2 (PKM2) is one of the rate‑limiting enzymes in the glycolytic process. PKM2 is considered to serve an important role in several terminal diseases, including sepsis. However, to the best of our knowledge, the specific mechanistic role of PKM2 in sepsis remains to be systematically summarised. Therefore, the present review aims to summarise the roles of PKM2 in sepsis progression. In addition, potential treatment strategies for patients with sepsis are discussed. The present review hopes to lay the groundwork for studying the role of PKM2 and developing therapeutic strategies against metabolic disorders that occur during sepsis.
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October-2024
Volume 30 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Hu Y, Tang J, Xu Q, Fang Z, Li R, Yang M, Zhao J and Chen X: Role of pyruvate kinase M2 in regulating sepsis (Review). Mol Med Rep 30: 185, 2024.
APA
Hu, Y., Tang, J., Xu, Q., Fang, Z., Li, R., Yang, M. ... Chen, X. (2024). Role of pyruvate kinase M2 in regulating sepsis (Review). Molecular Medicine Reports, 30, 185. https://doi.org/10.3892/mmr.2024.13309
MLA
Hu, Y., Tang, J., Xu, Q., Fang, Z., Li, R., Yang, M., Zhao, J., Chen, X."Role of pyruvate kinase M2 in regulating sepsis (Review)". Molecular Medicine Reports 30.4 (2024): 185.
Chicago
Hu, Y., Tang, J., Xu, Q., Fang, Z., Li, R., Yang, M., Zhao, J., Chen, X."Role of pyruvate kinase M2 in regulating sepsis (Review)". Molecular Medicine Reports 30, no. 4 (2024): 185. https://doi.org/10.3892/mmr.2024.13309