Open Access

Roles of small GTPases in cardiac hypertrophy (Review)

  • Authors:
    • Xin Wang
    • Xinwen Nie
    • Hao Wang
    • Zhanhong Ren
  • View Affiliations

  • Published online on: September 19, 2024     https://doi.org/10.3892/mmr.2024.13332
  • Article Number: 208
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiac hypertrophy results from the heart reacting and adapting to various pathological stimuli and its persistent development is a major contributing factor to heart failure. However, the molecular mechanisms of cardiac hypertrophy remain unclear. Small GTPases in the Ras, Rho, Rab, Arf and Ran subfamilies exhibit GTPase activity and play crucial roles in regulating various cellular responses. Previous studies have shown that Ras, Rho and Rab are closely linked to cardiac hypertrophy and that their overexpression can induce cardiac hypertrophy. Here, we review the functions of small GTPases in cardiac hypertrophy and provide additional insights and references for the prevention and treatment of cardiac hypertrophy.
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November-2024
Volume 30 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Nie X, Wang H and Ren Z: Roles of small GTPases in cardiac hypertrophy (Review). Mol Med Rep 30: 208, 2024.
APA
Wang, X., Nie, X., Wang, H., & Ren, Z. (2024). Roles of small GTPases in cardiac hypertrophy (Review). Molecular Medicine Reports, 30, 208. https://doi.org/10.3892/mmr.2024.13332
MLA
Wang, X., Nie, X., Wang, H., Ren, Z."Roles of small GTPases in cardiac hypertrophy (Review)". Molecular Medicine Reports 30.5 (2024): 208.
Chicago
Wang, X., Nie, X., Wang, H., Ren, Z."Roles of small GTPases in cardiac hypertrophy (Review)". Molecular Medicine Reports 30, no. 5 (2024): 208. https://doi.org/10.3892/mmr.2024.13332