search button
Open Access

Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review)

  • Authors:
    • Ling Wang
    • Xin Li
    • Xiaoju Men
    • Xiangyi Liu
    • Jinque Luo

  • View Affiliations

  • Published online on: November 7, 2024     https://doi.org/10.3892/mmr.2024.13387
  • Article Number: 22

  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cataracts are primarily caused by aging or gene mutations and are the leading cause of blindness globally. As the older population increases, the number of patients with a cataract is expected to grow rapidly. At present, cataract surgery to replace the lens with an artificial intraocular lens is the principal treatment method. However, surgery has several drawbacks, including economic burdens and complications such as inflammation, xerophthalmia, macular edema and posterior capsular opacification. Thus, developing an effective non‑surgical treatment strategy is beneficial to both patients and public health. Mechanistically, cataract formation may be due to various reasons but is primarily initiated and promoted by oxidative stress and is closely associated with crystallin aggregation. In the present review, the current research progress on anti‑cataract drugs, including antioxidants and protein aggregation inhibitors is examined. It summarizes strategies for preventing and treating cataract through cell apoptosis and protein aggregation inhibition while discussing their limitations and further prospects. 
View Figures
View References

Related Articles

Journal Cover

January-2025
Volume 31 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Li X, Men X, Liu X and Luo J: Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review). Mol Med Rep 31: 22, 2025.
APA
Wang, L., Li, X., Men, X., Liu, X., & Luo, J. (2025). Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review). Molecular Medicine Reports, 31, 22. https://doi.org/10.3892/mmr.2024.13387
MLA
Wang, L., Li, X., Men, X., Liu, X., Luo, J."Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review)". Molecular Medicine Reports 31.1 (2025): 22.
Chicago
Wang, L., Li, X., Men, X., Liu, X., Luo, J."Research progress on antioxidants and protein aggregation inhibitors in cataract prevention and therapy (Review)". Molecular Medicine Reports 31, no. 1 (2025): 22. https://doi.org/10.3892/mmr.2024.13387