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Research progress on the correlation between corneal neovascularization and lymphangiogenesis (Review)

  • Authors:
    • Zhaochen Zhang
    • Rongxuan Zhao
    • Xuhui Wu
    • Yunkun Ma
    • Yuxi He
  • View Affiliations

  • Published online on: December 3, 2024     https://doi.org/10.3892/mmr.2024.13412
  • Article Number: 47
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The cornea is a clear connective tissue membrane at the front of the outer layer of the eyeball wall. It plays a crucial role in the refractive system of the eyeball, making it essential to maintain its transparency. Neovascularization and lymphangiogenesis in the cornea significantly impact corneal transparency and immune privilege. The growth of corneal neovascularization (CNV) and corneal lymphangiogenesis (CL) vessels is interconnected yet independent. Currently, there is a substantial amount of clinical and experimental research on CNV and CL vessels. However, due to the relatively recent focus on CL vessel research compared with CNV research, most scholars tend to concentrate on CNV, with few articles offering a comprehensive comparison and discussion of the two processes. The present review emphasizes the similarities and differences between CNV and CL and summarizes recent research progress on their correlation in animal models, growth characteristics, cytokine effects and related diseases.
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February-2025
Volume 31 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Z, Zhao R, Wu X, Ma Y and He Y: Research progress on the correlation between corneal neovascularization and lymphangiogenesis (Review). Mol Med Rep 31: 47, 2025.
APA
Zhang, Z., Zhao, R., Wu, X., Ma, Y., & He, Y. (2025). Research progress on the correlation between corneal neovascularization and lymphangiogenesis (Review). Molecular Medicine Reports, 31, 47. https://doi.org/10.3892/mmr.2024.13412
MLA
Zhang, Z., Zhao, R., Wu, X., Ma, Y., He, Y."Research progress on the correlation between corneal neovascularization and lymphangiogenesis (Review)". Molecular Medicine Reports 31.2 (2025): 47.
Chicago
Zhang, Z., Zhao, R., Wu, X., Ma, Y., He, Y."Research progress on the correlation between corneal neovascularization and lymphangiogenesis (Review)". Molecular Medicine Reports 31, no. 2 (2025): 47. https://doi.org/10.3892/mmr.2024.13412