Open Access

Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)

  • Authors:
    • Pingping Tang
    • Jiale Wang
    • Xiaohan Tang
    • Yichun Li
    • Suyun Li
  • View Affiliations

  • Published online on: March 18, 2025     https://doi.org/10.3892/mmr.2025.13494
  • Article Number: 129
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Spermatogenesis dysfunction is characterized by abnormal morphology, destruction, atrophy of seminiferous tubules, blocked differentiation of spermatogenic cells, decreased sperm count and increased sperm abnormalities. Inflammation, oxidative stress, endoplasmic reticulum stress and obesity are important factors leading to spermatogenesis dysfunction. It has been demonstrated that insulin‑like growth factor 2 (IGF2) is closely related to the aforementioned factors. In the present review, the relationship between IGF2 and inflammation, oxidative stress, ER stress and obesity was investigated, providing theoretical and experimental evidence on the role of IGF2 in the prevention and treatment of spermatogenesis dysfunction of male infertility.
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May-2025
Volume 31 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Tang P, Wang J, Tang X, Li Y and Li S: Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review). Mol Med Rep 31: 129, 2025.
APA
Tang, P., Wang, J., Tang, X., Li, Y., & Li, S. (2025). Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review). Molecular Medicine Reports, 31, 129. https://doi.org/10.3892/mmr.2025.13494
MLA
Tang, P., Wang, J., Tang, X., Li, Y., Li, S."Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)". Molecular Medicine Reports 31.5 (2025): 129.
Chicago
Tang, P., Wang, J., Tang, X., Li, Y., Li, S."Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review)". Molecular Medicine Reports 31, no. 5 (2025): 129. https://doi.org/10.3892/mmr.2025.13494