Open Access

Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review)

  • Authors:
    • Weitong Sun
    • Shize Ma
    • Dongdong Meng
    • Chaoxing Wang
    • Jinbo Zhang
  • View Affiliations

  • Published online on: March 19, 2025     https://doi.org/10.3892/mmr.2025.13498
  • Article Number: 133
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The intestinal microbiota represents a diverse population that serves a key role in colorectal cancer (CRC) and its treatment outcomes. Advancements in sequencing have revealed notable shifts in microbial composition and diversity among individuals with CRC. Concurrently, animal models have elucidated the involvement of specific microbes such as Lactobacillus fragilis, Escherichia coli and Fusobacterium nucleatum in the progression of CRC. The present review aimed to highlight contributions of intestinal microbiota to the pathogenesis of CRC, the effects of traditional treatments on intestinal microbiota and the potential for microbiota modulation as a therapeutic strategy for CRC.
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May-2025
Volume 31 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Sun W, Ma S, Meng D, Wang C and Zhang J: Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review). Mol Med Rep 31: 133, 2025.
APA
Sun, W., Ma, S., Meng, D., Wang, C., & Zhang, J. (2025). Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review). Molecular Medicine Reports, 31, 133. https://doi.org/10.3892/mmr.2025.13498
MLA
Sun, W., Ma, S., Meng, D., Wang, C., Zhang, J."Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review)". Molecular Medicine Reports 31.5 (2025): 133.
Chicago
Sun, W., Ma, S., Meng, D., Wang, C., Zhang, J."Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review)". Molecular Medicine Reports 31, no. 5 (2025): 133. https://doi.org/10.3892/mmr.2025.13498