search button

Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR

  • Authors:
    • Ana Patrícia Barros Cordeiro
    • Fábio P.E. da Silva
    • Julio Cesar Pieczarka
    • Cleusa Yoshiko Nagamachi
    • Nilson Praia Anselmo
    • José Reginaldo Brito
    • Douglas S. Vasconcelos
    • Thomas Liehr
    • Anja Weise
    • Edivaldo H.C. de Oliveira

  • View Affiliations

  • Published online on: May 1, 2009     https://doi.org/10.3892/mmr_00000120
  • Pages: 449-454
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Meningiomas are generally slow-growing benign tumours; however, recurrent cases are associated with a poor prognosis. As these tumours are commonly grouped according to their grade of malignancy, it is difficult to define tumour-specific alterations involved in their genesis and evolution. Genetic comparative studies of primary and recurrent tumours are important for the identification of the chromosomal, genetic and proliferative alterations that are possibly involved in the process of malignancy in this class of tumour. We performed interphase fluorescence in situ hybridization using region-specific probes comprising the genes MYCN, ERBB4, CDH1, ABR, ERBB2 and NF2 as well as AgNOR staining in a sample of primary and relapsed chordoid meningiomas. Significant differences were found in these samples regarding the genes NF2, MYCN, ABR and ERBB2. Cell proliferation levels also showed a significant difference. The results suggest the involvement of the MYCN gene in the evolution of meningiomas.

Related Articles

Journal Cover

May-June 2009
Volume 2 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Cordeiro AP, da Silva FP, Pieczarka JC, Nagamachi CY, Anselmo NP, Brito JR, Vasconcelos DS, Liehr T, Weise A, de Oliveira EH, de Oliveira EH, et al: Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR. Mol Med Rep 2: 449-454, 2009.
APA
Cordeiro, A.P., da Silva, F.P., Pieczarka, J.C., Nagamachi, C.Y., Anselmo, N.P., Brito, J.R. ... de Oliveira, E.H. (2009). Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR. Molecular Medicine Reports, 2, 449-454. https://doi.org/10.3892/mmr_00000120
MLA
Cordeiro, A. P., da Silva, F. P., Pieczarka, J. C., Nagamachi, C. Y., Anselmo, N. P., Brito, J. R., Vasconcelos, D. S., Liehr, T., Weise, A., de Oliveira, E. H."Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR". Molecular Medicine Reports 2.3 (2009): 449-454.
Chicago
Cordeiro, A. P., da Silva, F. P., Pieczarka, J. C., Nagamachi, C. Y., Anselmo, N. P., Brito, J. R., Vasconcelos, D. S., Liehr, T., Weise, A., de Oliveira, E. H."Comparative analysis of proliferative and genetic alterations in a primary chordoid meningioma and its recurrence using locus-specific probes and AgNOR". Molecular Medicine Reports 2, no. 3 (2009): 449-454. https://doi.org/10.3892/mmr_00000120