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Saponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells

  • Authors:
    • Jeung-Hyun Koo
    • Ikjae Lee
    • Seok-Kweon Yun
    • Han-Uk Kim
    • Byung-Hyun Park
    • Jin-Woo Park

  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/mmr_00000252
  • Pages: 281-285
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The purpose of this study was to determine whether saponified sunflower and safflower oils can potentially be used as whitening agents, and to investigate their underlying mechanisms. Saponified sunflower (sap-SU) and safflower (sap-SA) oils dose-dependently inhibited isobutylmethylxanthine-induced melanogenesis in B16 melanoma cells, with no cytotoxicity. This decrease in melanin production was correlated with reduced enzyme activity and decreased mRNA and protein levels of tyrosinase. mRNA levels of microphthalmia-associated transcription factor and tyrosinase-related proteins 1 and 2 were also decreased by sap-SU and sap-SA, indicating the regulation of tyrosinase at the transcriptional level. Taken together, these results suggest that sap-SU and sap-SA can potentially be used as cosmetic whitening agents.

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March-April 2010
Volume 3 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
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Spandidos Publications style
Koo J, Lee I, Yun S, Kim H, Park B and Park J: Saponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells . Mol Med Rep 3: 281-285, 2010.
APA
Koo, J., Lee, I., Yun, S., Kim, H., Park, B., & Park, J. (2010). Saponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells . Molecular Medicine Reports, 3, 281-285. https://doi.org/10.3892/mmr_00000252
MLA
Koo, J., Lee, I., Yun, S., Kim, H., Park, B., Park, J."Saponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells ". Molecular Medicine Reports 3.2 (2010): 281-285.
Chicago
Koo, J., Lee, I., Yun, S., Kim, H., Park, B., Park, J."Saponified sunflower and safflower oils inhibit melanogenesis in B16 melanoma cells ". Molecular Medicine Reports 3, no. 2 (2010): 281-285. https://doi.org/10.3892/mmr_00000252