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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-June 2010 Volume 3 Issue 3

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Article

microRNA regulation of the expression of the estrogen receptor in endometrial cancer

  • Authors:
    • Jing Zhou
    • Tianrong Song
    • Shipeng Gong
    • Mei Zhong
    • Guidong Su

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China
  • Pages: 387-392
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000269
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Abstract

microRNAs (miRNAs) are non-coding RNA transcripts thought to be instrumental in controlling eukaryotic cell function. This study aimed to identify miRNAs associated with the differential expression of estrogen receptor α (ERα) and progesterone receptor (PR) in uterine endometrial cancer. First, the pathology of Ishikawa and KLE cell lines was identified by transplant and biopsy. Expression levels of ERα and PR and their response to estrogen and progesterone were examined, and total RNA was isolated to identify differentially expressed miRNAs by microarray analysis. miRNAs targeting ESR1 and PGR were predicted by miRANDA and TargetScan software, and their expression levels in cell lines and in patient samples were validated by real-time RT-PCR. Ishikawa and KLE represent estrogen-dependent and estrogen-independent endometrial cancers, respectively. As identified by miRNA microarray, 126 miRNAs were differentially expressed between the two cell lines; hsa-miR-100 and hsa-miR-99a were predicted to target ESR1, and hsa-miR-378 and hsa-miR-768-3p to target PGR. The differential expression of these miRNAs between Ishikawa and KLE was consistent in vivo and in vitro. Hsa-miR-100 was significantly down-regulated in the estrogen-dependent endometrial cancer samples as compared to the estrogen-independent samples and thus has the potential to target ESR1.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Song T, Gong S, Zhong M and Su G: microRNA regulation of the expression of the estrogen receptor in endometrial cancer. Mol Med Rep 3: 387-392, 2010.
APA
Zhou, J., Song, T., Gong, S., Zhong, M., & Su, G. (2010). microRNA regulation of the expression of the estrogen receptor in endometrial cancer. Molecular Medicine Reports, 3, 387-392. https://doi.org/10.3892/mmr_00000269
MLA
Zhou, J., Song, T., Gong, S., Zhong, M., Su, G."microRNA regulation of the expression of the estrogen receptor in endometrial cancer". Molecular Medicine Reports 3.3 (2010): 387-392.
Chicago
Zhou, J., Song, T., Gong, S., Zhong, M., Su, G."microRNA regulation of the expression of the estrogen receptor in endometrial cancer". Molecular Medicine Reports 3, no. 3 (2010): 387-392. https://doi.org/10.3892/mmr_00000269
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Song T, Gong S, Zhong M and Su G: microRNA regulation of the expression of the estrogen receptor in endometrial cancer. Mol Med Rep 3: 387-392, 2010.
APA
Zhou, J., Song, T., Gong, S., Zhong, M., & Su, G. (2010). microRNA regulation of the expression of the estrogen receptor in endometrial cancer. Molecular Medicine Reports, 3, 387-392. https://doi.org/10.3892/mmr_00000269
MLA
Zhou, J., Song, T., Gong, S., Zhong, M., Su, G."microRNA regulation of the expression of the estrogen receptor in endometrial cancer". Molecular Medicine Reports 3.3 (2010): 387-392.
Chicago
Zhou, J., Song, T., Gong, S., Zhong, M., Su, G."microRNA regulation of the expression of the estrogen receptor in endometrial cancer". Molecular Medicine Reports 3, no. 3 (2010): 387-392. https://doi.org/10.3892/mmr_00000269
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