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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin

  • Authors:
    • Peng-Peng Wang
    • Min Lin
    • Jiao-Ren Wu
    • Xian-Yao Wang
    • Li-Ye Yang

  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Chaozhou Central Hospital, Chaozhou 521021, P.R. China
  • Pages: 459-461
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000280
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Abstract

Hemoglobin (Hb) G-Chinese [α30 (B11) Glu↷Gln], also known as Hb G-Honolulu, Hb G-Hongkong or Hb G-Singapore, was first identified in a Chinese woman in Singapore, and was subsequently observed in several Chinese families. This Hb variant results from a GAG↷CAG mutation at codon 30 of the α-globin gene. The aim of the present study was to identify the Hb G-Chinese mutation in three Cantonese individuals. The presence of the Hb variant was confirmed by cellulose acetate electrophoresis. DNA analysis based on the polymerase chain reaction (PCR) and sequencing were conducted to confirm the presence of the mutation in the α-globin gene. A G↷C substitution at codon 30 of the α2-globin gene was observed. According to a previous study, the G↷C substitution in Hb G-Chinese creates a PstI restriction site; we amplified the α2-globin gene, then digested the PCR products with PstI. The results indicated that only the PCR product of Hb G-Chinese α2-globin was cut by PstI. The digestive products were 120 and 730 bp, respectively. Therefore, we determined that the three cases were of the heterozygous Hb G-Chinese variant.

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Copy and paste a formatted citation
Spandidos Publications style
Wang P, Lin M, Wu J, Wang X and Yang L: Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin. Mol Med Rep 3: 459-461, 2010.
APA
Wang, P., Lin, M., Wu, J., Wang, X., & Yang, L. (2010). Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin. Molecular Medicine Reports, 3, 459-461. https://doi.org/10.3892/mmr_00000280
MLA
Wang, P., Lin, M., Wu, J., Wang, X., Yang, L."Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin". Molecular Medicine Reports 3.3 (2010): 459-461.
Chicago
Wang, P., Lin, M., Wu, J., Wang, X., Yang, L."Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin". Molecular Medicine Reports 3, no. 3 (2010): 459-461. https://doi.org/10.3892/mmr_00000280
Copy and paste a formatted citation
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Spandidos Publications style
Wang P, Lin M, Wu J, Wang X and Yang L: Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin. Mol Med Rep 3: 459-461, 2010.
APA
Wang, P., Lin, M., Wu, J., Wang, X., & Yang, L. (2010). Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin. Molecular Medicine Reports, 3, 459-461. https://doi.org/10.3892/mmr_00000280
MLA
Wang, P., Lin, M., Wu, J., Wang, X., Yang, L."Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin". Molecular Medicine Reports 3.3 (2010): 459-461.
Chicago
Wang, P., Lin, M., Wu, J., Wang, X., Yang, L."Three cases of the hemoglobin G-Chinese variant detected in patients of southern Chinese origin". Molecular Medicine Reports 3, no. 3 (2010): 459-461. https://doi.org/10.3892/mmr_00000280
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