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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus

  • Authors:
    • Ok Joon Kim
    • Un-Kyung Kim
    • Seung Hun Oh
    • Yong Wook Cho
    • Kyung Im Oh
    • Doyeun Oh
    • Young Seok Park
    • Nam Keun Kim

  • View Affiliations / Copyright

    Affiliations: Department of Neurology, CHA University, Seongnam, Korea
  • Pages: 509-513
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000289
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Abstract

Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene have been implicated in various diseases associated with cardiovascular risk factors, but little is known regarding the risks of ischemic stroke (IS) in patients with diabetes mellitus (DM). In this study, we evaluated the genotypes and haplotypes of three eNOS polymorphisms (-786T>C, 4a4b and 894G>T) in a Korean population of 223 IS patients and 206 controls classified into four groups: healthy subjects, type 2 DM patients without IS, IS patients without type 2 DM and IS patients with type 2 DM. The genotype frequency of 4a4b in the controls with type 2 DM differed significantly from that in the controls without DM (4b4b vs. 4a4b; OR=2.769; 95% CI 1.233-6.220) and the frequency of the -786C-4a-894G haplotype was higher in the controls with DM compared to the controls without DM (P=0.040). Additionally, the -786C-4b-894G haplotype was more common in the cases with DM than in the controls without type 2 DM (P=0.034). Our findings suggest that the eNOS 4a allele-associated genotype and haplotype is a risk factor for type 2 DM, and that the -786C-4b-894G haplotype is a risk factor for IS with DM.

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Copy and paste a formatted citation
Spandidos Publications style
Kim OJ, Kim U, Oh SH, Cho YW, Oh KI, Oh D, Park YS and Kim NK: Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus. Mol Med Rep 3: 509-513, 2010.
APA
Kim, O.J., Kim, U., Oh, S.H., Cho, Y.W., Oh, K.I., Oh, D. ... Kim, N.K. (2010). Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus. Molecular Medicine Reports, 3, 509-513. https://doi.org/10.3892/mmr_00000289
MLA
Kim, O. J., Kim, U., Oh, S. H., Cho, Y. W., Oh, K. I., Oh, D., Park, Y. S., Kim, N. K."Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus". Molecular Medicine Reports 3.3 (2010): 509-513.
Chicago
Kim, O. J., Kim, U., Oh, S. H., Cho, Y. W., Oh, K. I., Oh, D., Park, Y. S., Kim, N. K."Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus". Molecular Medicine Reports 3, no. 3 (2010): 509-513. https://doi.org/10.3892/mmr_00000289
Copy and paste a formatted citation
x
Spandidos Publications style
Kim OJ, Kim U, Oh SH, Cho YW, Oh KI, Oh D, Park YS and Kim NK: Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus. Mol Med Rep 3: 509-513, 2010.
APA
Kim, O.J., Kim, U., Oh, S.H., Cho, Y.W., Oh, K.I., Oh, D. ... Kim, N.K. (2010). Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus. Molecular Medicine Reports, 3, 509-513. https://doi.org/10.3892/mmr_00000289
MLA
Kim, O. J., Kim, U., Oh, S. H., Cho, Y. W., Oh, K. I., Oh, D., Park, Y. S., Kim, N. K."Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus". Molecular Medicine Reports 3.3 (2010): 509-513.
Chicago
Kim, O. J., Kim, U., Oh, S. H., Cho, Y. W., Oh, K. I., Oh, D., Park, Y. S., Kim, N. K."Association of endothelial nitric oxide synthase polymorphisms and haplotypes with ischemic stroke in Korean individuals with or without diabetes mellitus". Molecular Medicine Reports 3, no. 3 (2010): 509-513. https://doi.org/10.3892/mmr_00000289
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