Epithelioid angiosarcoma of the kidney: A case report and literature review
- Authors:
- Hongyun Liu
- Xingang Huang
- Hua Chen
- Xuechun Wang
- Lei Chen
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Affiliations: Department of Pathology, Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Department of Radiology, Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Department of Physiology, Qingdao University Medical College, Qingdao, Shandong 266071, P.R. China
- Published online on: June 26, 2014 https://doi.org/10.3892/ol.2014.2292
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Pages:
1155-1158
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Abstract
Epithelioid angiosarcoma (EAS) is a rare disease which presents a great diagnostic challenge. The present study reports a case of EAS in the kidney in a 75‑year‑old male who presented with gross hematuria. An abdominal computed tomography scan revealed space‑occupying lesions of the right kidney and renal cell carcinoma was suspected. Histological examination of the resected specimens showed pleomorphic epithelioid cells with vesicular nuclei, prominent nucleoli and eosinophilic cytoplasm that lined irregular vascular spaces. Immunohistochemical staining revealed that the tumor cells were positive for AE1/AE3, cytokeratin (CK) 7, vimentin, cluster of differentiation (CD) 31 and E‑cadherin, but showed no staining for CD10, CD34, factor VIII, CK20, carcinoembryonic antigen or desmin. Based on the histopathological and immunohistochemical findings, the patient was diagnosed with epithelioid angiosarcoma. Postoperative radiation therapy was administered and no recurrence was observed six months after surgery.
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