Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells
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- Published online on: July 8, 2015 https://doi.org/10.3892/ol.2015.3467
- Pages: 1642-1648
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Abstract
Elevated expression of Aurora-B affects cell apoptosis and proliferation in a variety of solid tumors. However, the role of Aurora-B has been poorly evaluated in non‑small cell lung cancer (NSCLC). In the present study, it was found that Aurora‑B was overexpressed in tissue specimens obtained from 174 patients with lung cancer. It was also demonstrated that knockdown of Aurora‑B induces apoptosis and inhibits the growth of lung cancer A549 cells in vitro and in vivo. Furthermore, it was found that silencing Aurora‑B decreased the activity of the phosphoinositide 3‑kinase (PI3K)/AKT pathway. Therefore, it was concluded that knockdown of Aurora‑B induces apoptosis and inhibits growth in NSCLC A549 cells, in addition to inhibiting the activity of the PI3K/AKT signaling pathway. Targeting Aurora-B may provide a novel target for lung cancer therapy.