Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges (Review)

  • Authors:
    • Jin‑Ku Lee
    • Do‑Hyun Nam
    • Jeongwu Lee
  • View Affiliations

  • Published online on: January 7, 2016     https://doi.org/10.3892/ol.2016.4074
  • Pages: 1281-1286
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Abstract

Glioblastoma multiforme (GBM) is the most common and most lethal primary brain tumor, with tragically little therapeutic progress over the last 30 years. Surgery provides a modest benefit, and GBM cells are resistant to radiation and chemotherapy. Despite significant development of the molecularly targeting strategies, the clinical outcome of GBM patients remains dismal. The challenges inherent in developing effective GBM treatments have become increasingly clear, and include resistance to standard treatments, the blood‑brain barrier, resistance of GBM stem‑like cells, and the genetic complexity and molecular adaptability of GBM. Recent studies have collectively suggested that certain antipsychotics harbor antitumor effects and have potential utilities as anti‑GBM therapeutics. In the present review, the anti-tumorigenic effects and putative mechanisms of antipsychotics, and the challenges for the potential use of antipsychotic drugs as anti‑GBM therapeutics are reviewed.
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February-2016
Volume 11 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lee JK, Nam DH and Lee J: Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges (Review). Oncol Lett 11: 1281-1286, 2016.
APA
Lee, J., Nam, D., & Lee, J. (2016). Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges (Review). Oncology Letters, 11, 1281-1286. https://doi.org/10.3892/ol.2016.4074
MLA
Lee, J., Nam, D., Lee, J."Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges (Review)". Oncology Letters 11.2 (2016): 1281-1286.
Chicago
Lee, J., Nam, D., Lee, J."Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges (Review)". Oncology Letters 11, no. 2 (2016): 1281-1286. https://doi.org/10.3892/ol.2016.4074