Open Access

Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions

  • Authors:
    • Hua Yan
    • Ming‑Yuan Ren
    • Zheng‑Xiang Wang
    • Shi‑Jun Feng
    • Si Li
    • Yi Cheng
    • Cai‑Xia Hu
    • Shun‑Qiang Gao
    • Guo‑Qiang Zhang
  • View Affiliations

  • Published online on: February 14, 2017     https://doi.org/10.3892/ol.2017.5742
  • Pages: 2397-2402
  • Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been reported that zerumbone (ZER) has marked effects on the regulation of cell proliferation and migration in multiple types of cancer, and has anti‑cancer effects on various types of malignant cell. However, the effects and underlying molecular mechanisms of treatment with ZER on melanoma cells remain unclear. In the present study, the effect of treatment with ZER on the proliferation, migration and mitochondrial function of the human melanoma cell line CHL‑1 was investigated. The results of the present study indicated that treatment with ZER significantly inhibited CHL‑1 cell proliferation (P<0.001). Cell migration analysis further demonstrated that ZER inhibited the migration of CHL‑1 cells (P<0.001). Treatment with ZER significantly increased cellular reactive oxygen species levels (P<0.001), reduced matrix membrane potential (P<0.001), decreased ATP (P<0.001) and mitochondrial DNA (P<0.001) levels, and decreased mitochondrial transcription factor A mRNA levels (P=0.002). The results of the present study suggested that the inhibition of proliferation and migration was mediated by altered mitochondrial function. In conclusion, the results of the present study suggested that ZER has chemotherapeutic effects on human melanoma cells by altering mitochondrial function.

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April-2017
Volume 13 Issue 4

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Spandidos Publications style
Yan H, Ren MY, Wang ZX, Feng SJ, Li S, Cheng Y, Hu CX, Gao SQ and Zhang GQ: Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions. Oncol Lett 13: 2397-2402, 2017
APA
Yan, H., Ren, M., Wang, Z., Feng, S., Li, S., Cheng, Y. ... Zhang, G. (2017). Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions. Oncology Letters, 13, 2397-2402. https://doi.org/10.3892/ol.2017.5742
MLA
Yan, H., Ren, M., Wang, Z., Feng, S., Li, S., Cheng, Y., Hu, C., Gao, S., Zhang, G."Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions". Oncology Letters 13.4 (2017): 2397-2402.
Chicago
Yan, H., Ren, M., Wang, Z., Feng, S., Li, S., Cheng, Y., Hu, C., Gao, S., Zhang, G."Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions". Oncology Letters 13, no. 4 (2017): 2397-2402. https://doi.org/10.3892/ol.2017.5742