Open Access

Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles

  • Authors:
    • Zoya Cohen
    • Yair Maimon
    • Noah Samuels
    • Raanan Berger
  • View Affiliations

  • Published online on: February 17, 2017     https://doi.org/10.3892/ol.2017.5747
  • Pages:2642-2648
  • Copyright: © Cohen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer‑herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS‑inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS‑independent botanicals that displayed divergent botanical‑specific profiles. The correlation between sensitivity profiles of ROS‑inducing botanicals suggests a common mechanism of action, in contrast to the varied mechanism of ROS‑independent botanicals. This implies that the investigation of the anticancer activity of botanicals should start with the examination of ROS‑mediated activity. Further investigation of ROS sensitivity among various tumor types is required in order to guide research into developing evidence‑based guidelines in the use of botanicals for cancer treatment.

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April 2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Cohen, Z., Maimon, Y., Samuels, N., & Berger, R. (2017). Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles. Oncology Letters, 13, 2642-2648. https://doi.org/10.3892/ol.2017.5747
MLA
Cohen, Z., Maimon, Y., Samuels, N., Berger, R."Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles". Oncology Letters 13.4 (2017): 2642-2648.
Chicago
Cohen, Z., Maimon, Y., Samuels, N., Berger, R."Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles". Oncology Letters 13, no. 4 (2017): 2642-2648. https://doi.org/10.3892/ol.2017.5747