Open Access

SATB1 promotes epithelial‑mesenchymal transition and metastasis in prostate cancer

  • Authors:
    • Honggang Qi
    • Xinyang Fu
    • Yeping Li
    • Xiang Pang
    • Sansan Chen
    • Xiaojun Zhu
    • Fei Li
    • Wanlong Tan
  • View Affiliations

  • Published online on: February 22, 2017     https://doi.org/10.3892/ol.2017.5765
  • Pages: 2577-2582
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Special AT‑rich sequence‑binding protein‑1 (SATB1) is associated with cancer progression and poor clinical outcome. The present study aims to evaluate whether SATB1 affects the biological behaviors of prostate cancer (PCa), and furthermore, to elucidate whether this effect works through the epithelial‑mesenchymal transition (EMT) pathway. Firstly, the expression of SATB1 was investigated in a series of PCa tissues as well as in a panel of PCa cell lines. Cell proliferation, migration and invasion were evaluated in SATB1 knockdown and overexpressed PCa cell lines by MTT and Transwell assays. The results showed that the expression of SATB1 was markedly upregulated in PCa tissues and all PCa cell lines (P<0.001). Ectopic expression of SATB1 promoted PCa cell proliferation and migration. Knockdown of SATB1 repressed the ability of cell proliferation and migration of PCa cells. In addition, inhibition of SATB1 could reverse the EMT processes through upregulation of E‑cadherin and downregulation of vimentin. The present study provided evidence that SATB1 may act as a potential therapeutic target in PCa patients.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Qi H, Fu X, Li Y, Pang X, Chen S, Zhu X, Li F and Tan W: SATB1 promotes epithelial‑mesenchymal transition and metastasis in prostate cancer. Oncol Lett 13: 2577-2582, 2017
APA
Qi, H., Fu, X., Li, Y., Pang, X., Chen, S., Zhu, X. ... Tan, W. (2017). SATB1 promotes epithelial‑mesenchymal transition and metastasis in prostate cancer. Oncology Letters, 13, 2577-2582. https://doi.org/10.3892/ol.2017.5765
MLA
Qi, H., Fu, X., Li, Y., Pang, X., Chen, S., Zhu, X., Li, F., Tan, W."SATB1 promotes epithelial‑mesenchymal transition and metastasis in prostate cancer". Oncology Letters 13.4 (2017): 2577-2582.
Chicago
Qi, H., Fu, X., Li, Y., Pang, X., Chen, S., Zhu, X., Li, F., Tan, W."SATB1 promotes epithelial‑mesenchymal transition and metastasis in prostate cancer". Oncology Letters 13, no. 4 (2017): 2577-2582. https://doi.org/10.3892/ol.2017.5765