Open Access

Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients

  • Authors:
    • Ronghui Cheng
    • Hongmei Yong
    • Yunhong Xia
    • Qingsong Xie
    • Guangyi Gao
    • Xueyi Zhou
  • View Affiliations

  • Published online on: February 23, 2017     https://doi.org/10.3892/ol.2017.5769
  • Pages: 2703-2707
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the effect of combined sorafenib chemotherapy on hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression and survival time of patients with advanced gastric cancer. From January 2010 to December 2011, 92 patients diagnosed with advanced gastric cancer were selected and randomly divided into the treatment group and control group. The treatment group was treated with sorafenib chemotherapy combined with 5-fluorouracil (5-FU), and the control group received 5-FU. The treatment course was 3-4 cycles. During the same period, 46 healthy persons admitted to the Second People's Hospital of Huaian were selected as the controls. A volume of 3-4 ml peripheral blood from each patient and control was collected before and after treatment. The expression levels of HIF-1α and VEGF in peripheral blood were measured by ELISA. The survival time of patients with advanced gastric cancer was followed and analyzed. Compared with healthy controls, serum levels of HIF-1α and VEGF were significantly higher in patients with advanced gastric cancer (P<0.05). After chemotherapy combined with sorafenib, the peripheral blood levels of HIF-1α and VEGF decreased significantly in the treatment group (P<0.05). The 5-year survival rate of patients in the two groups was followed. Compared with the control group, the 1-year survival rate of the treatment group was significantly higher (P<0.05). In conclusion, chemotherapy combined with sorafenib can effectively reduce serum levels of HIF-1α and VEGF in patients with advanced gastric cancer, and improve their 1-year survival rate and prognosis. Therefore, it has significant clinical application value.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
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Spandidos Publications style
Cheng R, Yong H, Xia Y, Xie Q, Gao G and Zhou X: Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients. Oncol Lett 13: 2703-2707, 2017
APA
Cheng, R., Yong, H., Xia, Y., Xie, Q., Gao, G., & Zhou, X. (2017). Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients. Oncology Letters, 13, 2703-2707. https://doi.org/10.3892/ol.2017.5769
MLA
Cheng, R., Yong, H., Xia, Y., Xie, Q., Gao, G., Zhou, X."Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients". Oncology Letters 13.4 (2017): 2703-2707.
Chicago
Cheng, R., Yong, H., Xia, Y., Xie, Q., Gao, G., Zhou, X."Chemotherapy regimen based on sorafenib combined with 5-FU on HIF-1α and VEGF expression and survival in advanced gastric cancer patients". Oncology Letters 13, no. 4 (2017): 2703-2707. https://doi.org/10.3892/ol.2017.5769