De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report

Panelli Santos,Karina  Cecília; Matsuzaki,Hidenobu; Unetsubo,Teruhisa; Tsuyoshi,Shimo; Nagatsuka,Hitoshi; Asaumi,Jun‑Ichi

doi:10.3892/ol.2017.5783

De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report

Authors:
- Karina Cecília Panelli Santos
- Hidenobu Matsuzaki
- Teruhisa Unetsubo
- Shimo Tsuyoshi
- Hitoshi Nagatsuka
- Jun‑Ichi Asaumi
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Affiliations: Department of Oral and Maxillofacial Radiology, Field of Tumor Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita‑ku, Okayama 700‑8558, Japan, Department of Oral Diagnosis and Dentomaxillofacial Radiology, Okayama University Hospital, Kita‑ku, Okayama 700‑8558, Japan, Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita‑ku, Okayama 700‑8558, Japan, Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita‑ku, Okayama 700‑8558, Japan
Published online on: February 28, 2017 https://doi.org/10.3892/ol.2017.5783
Pages: 2679-2683
Copyright: © Panelli Santos et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki‑67.