Open Access

Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma

  • Authors:
    • Wenjun Lin
    • Lu Wang
    • Shengwu Yang
    • Xin Chen
    • Xiongbai Zhu
    • Piji Chen
  • View Affiliations

  • Published online on: May 16, 2018     https://doi.org/10.3892/ol.2018.8709
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Abstract

Expression of human serum albumin-micro RNA miR-148b in patients with stage-I and II parosteal osteosarcoma and its effect on prognosis were investigated. A total of 47 cases of fresh tissues of stage-I and II parosteal osteosarcoma and the corresponding para-carcinoma normal bone tissues resected by operation were collected; the expression of miR-148b in parosteal osteosarcoma tissues and normal bone tissues was detected, and the correlations of miR-148b expression in parosteal osteosarcoma tissues with clinicopathological parameters and prognosis were analyzed. The expression level of miR-148b in parosteal osteosarcoma tissues was significantly lower than that in para-carcinoma normal tissues (P<0.05). It was found that the low expression of miR-148b was correlated with the lung metastasis (P<0.05). Moreover, Kaplan-Meier survival curve analysis showed that the overall survival rate of patients in the low-expression miR-148b group was lower than that in the high-expression group (P<0.05). Multivariate Cox regression analysis revealed that the miR-148b level (P=0.003) was an independent prognostic factor affecting the prognosis. The results of this study showed that the expression of miR-148b in stage-I and II parosteal osteosarcoma tissues declines, which is related to the poor clinical prognosis of parosteal osteosarcoma.

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Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Lin, W., Wang, L., Yang, S., Chen, X., Zhu, X., & Chen, P. (1899). Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma. Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2018.8709
MLA
Lin, W., Wang, L., Yang, S., Chen, X., Zhu, X., Chen, P."Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma". Oncology Letters 0.0 (1899): 0-0.
Chicago
Lin, W., Wang, L., Yang, S., Chen, X., Zhu, X., Chen, P."Analysis of miR-148b expression differences in stage-I and II parosteal osteosarcoma". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2018.8709