Open Access

Efficacy of cadonilimab and anlotinib combination in treating multiple drug‑resistant pulmonary large cell neuroendocrine carcinoma: A case report and literature review

  • Authors:
    • Xi Qin
    • Yulan Liu
    • Lin Zhu
    • Lieyin Xu
    • Jinfu Lv
    • Yunyan Mo
    • Mafei Kang
    • Feng Xue
  • View Affiliations

  • Published online on: October 24, 2024     https://doi.org/10.3892/ol.2024.14773
  • Article Number: 27
  • Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pulmonary large cell neuroendocrine carcinoma (LCNEC) has a poor prognosis, and there is no consensus on optimal treatment strategies for pulmonary LCNEC. Certain patients with pulmonary LCNEC may benefit from targeted and traditional programmed cell death protein‑1 (PD‑1) monoclonal antibody therapies, however, for most patients, only a few drugs are effective after chemotherapy. The present report describes the case of a 68‑year‑old man with advanced pulmonary LCNEC treated with cadonilimab and anlotinib after becoming resistant to PD‑1 monoclonal antibody therapy and multiple chemotherapies. Computed tomography was used to evaluate treatment response. The treatment was efficacious and met the partial response criteria after three treatment cycles, and the coughing and dyspnea resolved. The primary mass and lymph node metastases continued to shrink after five treatment cycles. Therefore, the present case report suggests that a combination of cadonilimab and anlotinib is a potential treatment strategy for patients with pulmonary LCNEC.

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Copy and paste a formatted citation
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Spandidos Publications style
Qin X, Liu Y, Zhu L, Xu L, Lv J, Mo Y, Kang M and Xue F: Efficacy of cadonilimab and anlotinib combination in treating multiple drug‑resistant pulmonary large cell neuroendocrine carcinoma: A case report and literature review. Oncol Lett 29: 27, 2025.
APA
Qin, X., Liu, Y., Zhu, L., Xu, L., Lv, J., Mo, Y. ... Xue, F. (2025). Efficacy of cadonilimab and anlotinib combination in treating multiple drug‑resistant pulmonary large cell neuroendocrine carcinoma: A case report and literature review. Oncology Letters, 29, 27. https://doi.org/10.3892/ol.2024.14773
MLA
Qin, X., Liu, Y., Zhu, L., Xu, L., Lv, J., Mo, Y., Kang, M., Xue, F."Efficacy of cadonilimab and anlotinib combination in treating multiple drug‑resistant pulmonary large cell neuroendocrine carcinoma: A case report and literature review". Oncology Letters 29.1 (2025): 27.
Chicago
Qin, X., Liu, Y., Zhu, L., Xu, L., Lv, J., Mo, Y., Kang, M., Xue, F."Efficacy of cadonilimab and anlotinib combination in treating multiple drug‑resistant pulmonary large cell neuroendocrine carcinoma: A case report and literature review". Oncology Letters 29, no. 1 (2025): 27. https://doi.org/10.3892/ol.2024.14773