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Postoperative metastatic Krukenberg tumors with ARID1A and KRAS mutations in a patient with gastric cancer treated with oxaliplatin and tegafur: A case report

  • Authors:
    • Jie Wu
    • Suzhen Jiang
    • Qingling Shen
    • Hongxia Gong
  • View Affiliations

  • Published online on: April 2, 2025     https://doi.org/10.3892/ol.2025.15008
  • Article Number: 262
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Krukenberg tumors are a notably rare type of metastatic ovarian malignant tumor, often originating from the stomach. Due to their low incidence rate and the short survival time of patients, there is currently a lack of consensus on the diagnosis and treatment of this disease, as well as a deficiency in genomic analyses and research into the pathogenetic molecular mechanisms. In the present study, the case of a patient with gastric cancer who, 2 years after curative surgery and chemotherapy with oxaliplatin and tegafur, developed recurrent metastatic bilateral Krukenberg tumors with distant metastasis in the ovaries. During treatment, a total hysterectomy and bilateral salpingo‑oophorectomy were performed, and intraoperative intraperitoneal chemotherapy with cisplatin (70 mg) was administered. Additionally, ureteroscopy and bilateral ureteral stent placement were conducted transurethrally. Post‑surgery, assessments of the genomic alterations and microsatellite instability of the tumor revealed an AT‑rich interaction domain 1A (ARID1A) exon c.4720delC mutation and a KRAS exon c.35G>C mutation. The potential pathogenic mechanisms and clinical significance of these mutations were then further discussed. Mutations in the ARID1A gene could increase the sensitivity of the patient to immune checkpoint inhibitor therapy. Additionally, the successful application of KRASG12C inhibitors in other cancer types offers a new approach for the targeted therapy of Krukenberg tumors. Therefore, the present study provides further evidence regarding the genomics of Krukenberg tumors, which may aid in the development of targeted treatment strategies.
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June-2025
Volume 29 Issue 6

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Spandidos Publications style
Wu J, Jiang S, Shen Q and Gong H: Postoperative metastatic Krukenberg tumors with <em>ARID1A</em> and <em>KRAS</em> mutations in a patient with gastric cancer treated with oxaliplatin and tegafur: A case report. Oncol Lett 29: 262, 2025.
APA
Wu, J., Jiang, S., Shen, Q., & Gong, H. (2025). Postoperative metastatic Krukenberg tumors with <em>ARID1A</em> and <em>KRAS</em> mutations in a patient with gastric cancer treated with oxaliplatin and tegafur: A case report. Oncology Letters, 29, 262. https://doi.org/10.3892/ol.2025.15008
MLA
Wu, J., Jiang, S., Shen, Q., Gong, H."Postoperative metastatic Krukenberg tumors with <em>ARID1A</em> and <em>KRAS</em> mutations in a patient with gastric cancer treated with oxaliplatin and tegafur: A case report". Oncology Letters 29.6 (2025): 262.
Chicago
Wu, J., Jiang, S., Shen, Q., Gong, H."Postoperative metastatic Krukenberg tumors with <em>ARID1A</em> and <em>KRAS</em> mutations in a patient with gastric cancer treated with oxaliplatin and tegafur: A case report". Oncology Letters 29, no. 6 (2025): 262. https://doi.org/10.3892/ol.2025.15008