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ALTERED BINDING OF THE AP-1 PROTEIN ON A NEGATIVE REGULATORY ELEMENT OF C-MYC IS CORRELATED WITH THE PROGRESSION OF THE MALIGNANCY OF THE LUNG AND MAY CONTRIBUTE TO C-MYC EXPRESSION

  • Authors:
    • AG ELIOPOULOS
    • DA SPANDIDOS

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  • Published online on: January 1, 1994     https://doi.org/10.3892/or.1.1.139
  • Pages: 139-143
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Abstract

The binding activity of the AP-1 (FOS/JUN) complex to a negative regulatory element on the c-myc promoter was investigated in 7 tumour- versus normal lung specimens and it correlated with c-myc expression. AP-1 levels were found elevated in two samples representing stage I progression of the disease, while in three stage III tumour samples, the AP-1 binding activity was equal or slightly elevated compared with their normal adjacent tissue. Southern blot analysis revealed amplified c-myc in all three cases of stage III tumours. These results suggest that there is a negative correlation between FOS/JUN binding on c-myc promoter and the expression of c-myc during the progression of the disease, further supporting the fundamental role of AP-1 on c-myc regulation.

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January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
ELIOPOULOS A and SPANDIDOS D: ALTERED BINDING OF THE AP-1 PROTEIN ON A NEGATIVE REGULATORY ELEMENT OF C-MYC IS CORRELATED WITH THE PROGRESSION OF THE MALIGNANCY OF THE LUNG AND MAY CONTRIBUTE TO C-MYC EXPRESSION. Oncol Rep 1: 139-143, 1994.
APA
ELIOPOULOS, A., & SPANDIDOS, D. (1994). ALTERED BINDING OF THE AP-1 PROTEIN ON A NEGATIVE REGULATORY ELEMENT OF C-MYC IS CORRELATED WITH THE PROGRESSION OF THE MALIGNANCY OF THE LUNG AND MAY CONTRIBUTE TO C-MYC EXPRESSION. Oncology Reports, 1, 139-143. https://doi.org/10.3892/or.1.1.139
MLA
ELIOPOULOS, A., SPANDIDOS, D."ALTERED BINDING OF THE AP-1 PROTEIN ON A NEGATIVE REGULATORY ELEMENT OF C-MYC IS CORRELATED WITH THE PROGRESSION OF THE MALIGNANCY OF THE LUNG AND MAY CONTRIBUTE TO C-MYC EXPRESSION". Oncology Reports 1.1 (1994): 139-143.
Chicago
ELIOPOULOS, A., SPANDIDOS, D."ALTERED BINDING OF THE AP-1 PROTEIN ON A NEGATIVE REGULATORY ELEMENT OF C-MYC IS CORRELATED WITH THE PROGRESSION OF THE MALIGNANCY OF THE LUNG AND MAY CONTRIBUTE TO C-MYC EXPRESSION". Oncology Reports 1, no. 1 (1994): 139-143. https://doi.org/10.3892/or.1.1.139