THE ADDITION OF MESNA TO HYPERHYDRATION DOES NOT DECREASE THE INCIDENCE OF HEMORRHAGIC CYSTITIS IN PATIENTS RECEIVING HIGH-DOSE CYCLOPHOSPHAMIDE
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- Published online on: January 1, 1994 https://doi.org/10.3892/or.1.1.265
- Pages: 265-266
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Abstract
To assess the efficacy of hyperhydration Versus hyperhydration plus mesna in preventing cyclophosphamide induced hemorrhagic cystitis a retrospective analysis was conducted of 110 patients who received hyperhydration alone (baseline intravenous intake of at least 3.6 1/m(2)/day) and 107 patients who received hyperhydration plus mesna (120% of daily cyclophosphamide dose) while receiving cyclophosphamide (total dose 150-200 mg/kg) as part of a dose intensive regimen. Macroscopic hematuria was noted in 17 (16%) and 9 (8%) patients who received hyperhydration with or without mesna, respectively (p=0.08). This analysis failed to demonstrate a benefit in adding mesna to hyperhydration alone in preventing cyclophosphamide induced hemorrhagic cystitis.