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THE INFLUENCE OF INTESTINAL METAPLASIA ON DEVELOPMENT OF GASTRIC TUMORS IN WISTAR RATS RECEIVING X-RAYS AND MNNG, MNU OR DMH

  • Authors:
    • H WATANABE
    • Y ANDO
    • K YAMADA
    • T OKAMOTO
    • A ITO

  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/or.1.3.497
  • Pages: 497-501
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Abstract

Five-week-old male Wistar:Crj rats received two 10 Gy doses of X-rays to the gastric region at a 3-day interval. Two months thereafter the animals were treated with 100 mg/liter of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 4 months in their drinking water, N-methyl-N-nitrosourea (MNU) 2 mg/l ml/weekly/ for a total of 10 times by gastric intubation, or dimethylhydrazine (DMH) 20 mg/kg i.m./weekly/20 times. After 1 year, the animals were sacrificeded. There was thus no direct evidence of a histogenetic link between intestinal metaplasia and gastric carcinogenesis in the present results.

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May 1994
Volume 1 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
WATANABE H, ANDO Y, YAMADA K, OKAMOTO T and ITO A: THE INFLUENCE OF INTESTINAL METAPLASIA ON DEVELOPMENT OF GASTRIC TUMORS IN WISTAR RATS RECEIVING X-RAYS AND MNNG, MNU OR DMH. Oncol Rep 1: 497-501, 1994.
APA
WATANABE, H., ANDO, Y., YAMADA, K., OKAMOTO, T., & ITO, A. (1994). THE INFLUENCE OF INTESTINAL METAPLASIA ON DEVELOPMENT OF GASTRIC TUMORS IN WISTAR RATS RECEIVING X-RAYS AND MNNG, MNU OR DMH. Oncology Reports, 1, 497-501. https://doi.org/10.3892/or.1.3.497
MLA
WATANABE, H., ANDO, Y., YAMADA, K., OKAMOTO, T., ITO, A."THE INFLUENCE OF INTESTINAL METAPLASIA ON DEVELOPMENT OF GASTRIC TUMORS IN WISTAR RATS RECEIVING X-RAYS AND MNNG, MNU OR DMH". Oncology Reports 1.3 (1994): 497-501.
Chicago
WATANABE, H., ANDO, Y., YAMADA, K., OKAMOTO, T., ITO, A."THE INFLUENCE OF INTESTINAL METAPLASIA ON DEVELOPMENT OF GASTRIC TUMORS IN WISTAR RATS RECEIVING X-RAYS AND MNNG, MNU OR DMH". Oncology Reports 1, no. 3 (1994): 497-501. https://doi.org/10.3892/or.1.3.497