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IMMUNOHISTOCHEMICAL STUDY ON CATHEPSIN-B AND CATHEPSIN-D IN PANCREATIC-CANCER

  • Authors:
    • B NAKATA
    • HE APPERT
    • SZ LEI
    • Y YAMASHITA
    • YS CHUNG
    • M SOWA
    • JL MYLES
    • CA MAO
    • JM HOWARD

  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/or.1.3.543
  • Pages: 543-546
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Abstract

Lysosomal enzymes, cathepsin B and D, have been studied in their possible relationship to the ability of malignant cells to invade and metastasize. In the current investigation, these cathepsins were detected immunohistochemically using avidin-biotin-peroxidase complex method in the pancreatic cancer cells of 21 patients. The positive rate of identification of cathepsin B and D was 43% and 81%, respectively. Cathepsin D stained more strongly than cathepsin B and the plasma membrane stained quite strongly in two instances. A correlation between the presence of cathepsin B or D in cancer cells and the degree of metastasis to lymph nodes, liver, or lung was not recognized.

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Journal Cover

May 1994
Volume 1 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
NAKATA B, APPERT H, LEI S, YAMASHITA Y, CHUNG Y, SOWA M, MYLES J, MAO C and HOWARD J: IMMUNOHISTOCHEMICAL STUDY ON CATHEPSIN-B AND CATHEPSIN-D IN PANCREATIC-CANCER. Oncol Rep 1: 543-546, 1994.
APA
NAKATA, B., APPERT, H., LEI, S., YAMASHITA, Y., CHUNG, Y., SOWA, M. ... HOWARD, J. (1994). IMMUNOHISTOCHEMICAL STUDY ON CATHEPSIN-B AND CATHEPSIN-D IN PANCREATIC-CANCER. Oncology Reports, 1, 543-546. https://doi.org/10.3892/or.1.3.543
MLA
NAKATA, B., APPERT, H., LEI, S., YAMASHITA, Y., CHUNG, Y., SOWA, M., MYLES, J., MAO, C., HOWARD, J."IMMUNOHISTOCHEMICAL STUDY ON CATHEPSIN-B AND CATHEPSIN-D IN PANCREATIC-CANCER". Oncology Reports 1.3 (1994): 543-546.
Chicago
NAKATA, B., APPERT, H., LEI, S., YAMASHITA, Y., CHUNG, Y., SOWA, M., MYLES, J., MAO, C., HOWARD, J."IMMUNOHISTOCHEMICAL STUDY ON CATHEPSIN-B AND CATHEPSIN-D IN PANCREATIC-CANCER". Oncology Reports 1, no. 3 (1994): 543-546. https://doi.org/10.3892/or.1.3.543