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MOLECULAR-CLONING OF THE HUMAN CYCG1 GENE ENCODING A G-TYPE CYCLIN - OVEREXPRESSION IN HUMAN OSTEOSARCOMA CELLS

  • Authors:
    • LT WU
    • L LIU
    • A YEE
    • D CARBONARO-HALL
    • VT TOLO
    • FL HALL

  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/or.1.4.705
  • Pages: 705-711
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Cyclins constitute a growing family of regulatory proteins that complex with, and activate, protein kinases involved in cell cycle control. Dysregulation of cyclin expression and/or cyclin-dependent kinase (cdk) activities may play a pivotal role in oncogenesis. In this report, we characterize a novel human cyclin gene by molecular cloning. This gene, designated CYCG1, encodes a human homologue of the rat G-type cyclin, exhibiting structural features and conserved sequence motifs of identified G(1) cyclins. The CYCG1 gene is expressed constitutively in synchronized human WI-38 fibroblasts and MG-63 osteosarcoma cells, which is reminiscent of CLN3 in Saccharomyces cerevisiae. Marked overexpression of CYCG1 is observed in a subset of human osteosarcoma cells, providing a potential link to cancer.

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July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
WU L, LIU L, YEE A, CARBONARO-HALL D, TOLO V and HALL F: MOLECULAR-CLONING OF THE HUMAN CYCG1 GENE ENCODING A G-TYPE CYCLIN - OVEREXPRESSION IN HUMAN OSTEOSARCOMA CELLS. Oncol Rep 1: 705-711, 1994.
APA
WU, L., LIU, L., YEE, A., CARBONARO-HALL, D., TOLO, V., & HALL, F. (1994). MOLECULAR-CLONING OF THE HUMAN CYCG1 GENE ENCODING A G-TYPE CYCLIN - OVEREXPRESSION IN HUMAN OSTEOSARCOMA CELLS. Oncology Reports, 1, 705-711. https://doi.org/10.3892/or.1.4.705
MLA
WU, L., LIU, L., YEE, A., CARBONARO-HALL, D., TOLO, V., HALL, F."MOLECULAR-CLONING OF THE HUMAN CYCG1 GENE ENCODING A G-TYPE CYCLIN - OVEREXPRESSION IN HUMAN OSTEOSARCOMA CELLS". Oncology Reports 1.4 (1994): 705-711.
Chicago
WU, L., LIU, L., YEE, A., CARBONARO-HALL, D., TOLO, V., HALL, F."MOLECULAR-CLONING OF THE HUMAN CYCG1 GENE ENCODING A G-TYPE CYCLIN - OVEREXPRESSION IN HUMAN OSTEOSARCOMA CELLS". Oncology Reports 1, no. 4 (1994): 705-711. https://doi.org/10.3892/or.1.4.705