ELEVATION OF INTERLEUKIN-2 PRODUCTION IN PERIPHERAL-BLOOD LYMPHOCYTES BY RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR IN OVARIAN-CANCER PATIENTS DURING COMBINATION CHEMOTHERAPY
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- Published online on: September 1, 1994 https://doi.org/10.3892/or.1.5.941
- Pages: 941-944
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Abstract
Interleukin-2 (IL-2) production and peripheral blood lymphocyte (PBL) subsets were measured in ovarian cancer patients who received cis-platinum based chemotherapy with or without recombinant human granulocyte colony stimulating factor (rhG-CSF). Additional treatment with rhC-CSF resulted in significant elevation of IL-2 production and highly differentiated natural killer (NK) cell counts, indicating that rhG-CSF may be helpful for enhancement of the cellular immunity in ovarian cancer patients.