Immunohistochemical analysis of transforming growth factor β in gallbladder cancer

  • Authors:
    • Keiichi Kitamura
    • Kazuhiko Kasuya
    • Akihiko Tsuchida
    • Akihiro Mimuro
    • Keiichiro Inoue
    • Toshiaki Aoki
    • Tatsuya Aoki
    • Yasuhisa Koyanagi
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/or.10.2.327
  • Pages: 327-332
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Abstract

TGF-β is highly expressed in various cancer cells, yet its mechanism suppressing the cell cycle fails and cell proliferation accelerates, resulting in carcinogenesis. However, there are only a very few reports on animal experiments or clinical specimens with regard to the TGF-β in gallbladder cancer. We performed immunohistochemical analysis of TGF-β expression with regard to cell proliferation, angiogenesis, and tumor cell infiltration in clinical specimens of gallbladder cancer. TGF-β immunoreactivity was significantly higher in advanced cancer than in early cancer. With regard to Ki-67 labeling index, there was no significant difference between early cancer and advanced one. There was no statistically significant difference of the density of pre-existing blood vessels (CD34) between TGF-β-positive group and negative one. The density of angiogenic vessels (CD105) was significantly greater in the TGF-β-positive group than in the negative one. Tumor-associated macrophage infiltration was significantly higher in the TGF-β-positive group than in the negative one. No statistically significant differences in cumulative survival rate were noted between patients in the TGF-β-positive and TGF-β-negative groups. In conclusion, our study revealed that in patients with gallbladder cancer, expression of TGF-β increases according to cancer progression and strongly influences angiogenesis and macrophage infiltration, which contributes to tumor proliferation, but acts weakly on cancer cells by itself.

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March-April 2003
Volume 10 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kitamura K, Kasuya K, Tsuchida A, Mimuro A, Inoue K, Aoki T, Aoki T and Koyanagi Y: Immunohistochemical analysis of transforming growth factor β in gallbladder cancer. Oncol Rep 10: 327-332, 2003.
APA
Kitamura, K., Kasuya, K., Tsuchida, A., Mimuro, A., Inoue, K., Aoki, T. ... Koyanagi, Y. (2003). Immunohistochemical analysis of transforming growth factor β in gallbladder cancer. Oncology Reports, 10, 327-332. https://doi.org/10.3892/or.10.2.327
MLA
Kitamura, K., Kasuya, K., Tsuchida, A., Mimuro, A., Inoue, K., Aoki, T., Aoki, T., Koyanagi, Y."Immunohistochemical analysis of transforming growth factor β in gallbladder cancer". Oncology Reports 10.2 (2003): 327-332.
Chicago
Kitamura, K., Kasuya, K., Tsuchida, A., Mimuro, A., Inoue, K., Aoki, T., Aoki, T., Koyanagi, Y."Immunohistochemical analysis of transforming growth factor β in gallbladder cancer". Oncology Reports 10, no. 2 (2003): 327-332. https://doi.org/10.3892/or.10.2.327