Frequent translocalization of β-catenin in gastric cancers and its relevance to tumor progression

  • Authors:
    • Xiao-Xin Cheng
    • Yuan Sun
    • Xiao-Yan Chen
    • Kai-Li Zhang
    • Qing-You Kong
    • Jia Liu
    • Hong Li
  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/or.11.6.1201
  • Pages: 1201-1207
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Altered distribution of β-catenin has been found in many human malignancies including gastric cancer, but its reason(s) and biological implications have not yet been fully clarified. By the methods of frozen tissue array-based immunohistochemistry, RT-PCR and PCR-SSCP followed by DNA sequencing, the patterns of β-catenin distribution in the subtypes of gastric cancers and their premalignant and non-cancerous counterparts were examined and the potential correlation of β-catenin alteration with invasion was elucidated. Membranous β-catenin was detected constantly in non-cancerous mucosa but became reduced or absent in cancer tissues. The cytoplasmic and nuclear accumulation of β-catenin could be observed in premalignant (atrophic gastritis and intestinal metaplasia) and cancer tissues, particularly in those infiltrated into deep muscular region. β-catenin mutation was not detected in all of tissue samples with and without translocalized β-catenin. These results indicate that β-catenin translocalization is a common phenomenon in gastric cancers as well as their related lesions. The loss of membranous and the gain of cytoplasmic and nuclear β-catenin in gastric cancers checked in this study are not due to the mutational event. β-catenin molecules translocalized in the nuclei are closely correlated with tumor invasion.

Related Articles

Journal Cover

June 2004
Volume 11 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng X, Sun Y, Chen X, Zhang K, Kong Q, Liu J and Li H: Frequent translocalization of β-catenin in gastric cancers and its relevance to tumor progression. Oncol Rep 11: 1201-1207, 2004.
APA
Cheng, X., Sun, Y., Chen, X., Zhang, K., Kong, Q., Liu, J., & Li, H. (2004). Frequent translocalization of β-catenin in gastric cancers and its relevance to tumor progression. Oncology Reports, 11, 1201-1207. https://doi.org/10.3892/or.11.6.1201
MLA
Cheng, X., Sun, Y., Chen, X., Zhang, K., Kong, Q., Liu, J., Li, H."Frequent translocalization of β-catenin in gastric cancers and its relevance to tumor progression". Oncology Reports 11.6 (2004): 1201-1207.
Chicago
Cheng, X., Sun, Y., Chen, X., Zhang, K., Kong, Q., Liu, J., Li, H."Frequent translocalization of β-catenin in gastric cancers and its relevance to tumor progression". Oncology Reports 11, no. 6 (2004): 1201-1207. https://doi.org/10.3892/or.11.6.1201