Expression of TAP73 and ΔNP73 in malignant gliomas

  • Authors:
    • Hasan Ugur
    • A. E. Sayan
    • Sukru O. Ozdamar
    • Yucel Kanpolat
    • Mehmet Ozturk
  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/or.11.6.1337
  • Pages: 1337-1341
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The p73 gene is able to encode transcriptionaly active TAp73, as well as a dominant-negatively acting ΔNp73 transcript isoforms. We studied differential expression of these forms in normal brain as well as glial tumors, by semiquantitative RT-PCR. The expression of p73 was low or undetectable in normal brain tissues. Most of the tumors and non-tumor brain tissues also lacked significant expression of p73 in patients with low-grade astrocytomas. In contrast, most high-grade glial tumors displayed strong up-regulation of TAp73, whereas only a few displayed ΔNp73 expression. These aberrations may reflect the inactivation of retinoblastoma pathway in these tumors which result in the activation of E2F transcription factors, since TAp73 is a known target of E2F1 gene. The study of TAp73 expression in brain tumors may serve as a means to evaluate the retinoblastoma pathway-dependent tumor progression.

Related Articles

Journal Cover

June 2004
Volume 11 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ugur H, Sayan AE, Ozdamar SO, Kanpolat Y and Ozturk M: Expression of TAP73 and ΔNP73 in malignant gliomas. Oncol Rep 11: 1337-1341, 2004.
APA
Ugur, H., Sayan, A.E., Ozdamar, S.O., Kanpolat, Y., & Ozturk, M. (2004). Expression of TAP73 and ΔNP73 in malignant gliomas. Oncology Reports, 11, 1337-1341. https://doi.org/10.3892/or.11.6.1337
MLA
Ugur, H., Sayan, A. E., Ozdamar, S. O., Kanpolat, Y., Ozturk, M."Expression of TAP73 and ΔNP73 in malignant gliomas". Oncology Reports 11.6 (2004): 1337-1341.
Chicago
Ugur, H., Sayan, A. E., Ozdamar, S. O., Kanpolat, Y., Ozturk, M."Expression of TAP73 and ΔNP73 in malignant gliomas". Oncology Reports 11, no. 6 (2004): 1337-1341. https://doi.org/10.3892/or.11.6.1337