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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2004 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2004 Volume 12 Issue 1

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Article

DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers

  • Authors:
    • Tetsuro Hanabata
    • Kazunori Tsukuda
    • Shinichi Toyooka
    • Masaaki Yano
    • Motoi Aoe
    • Itaru Nagahiro
    • Yoshifumi Sano
    • Hiroshi Date
    • Nobuyoshi Shimizu

  • View Affiliations / Copyright

    Affiliations: Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
  • Pages: 177-180
    |
    Published online on: July 1, 2004
       https://doi.org/10.3892/or.12.1.177
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Abstract

Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in several types of cancers. In non-small cell lung cancer (NSCLC), several genes are known to be frequently methylated and the correlation of their methylation with clinical features has been studied. We determined the methylation of p16, CDH13 and RAR-β which were reported to be methylated frequently in NSCLCs and HPP-1 which was known to be methylated in other types of cancers. The correlation between methylation and clinicopathological features were examined. The frequencies of methylation in NSCLCs were 20% for p16, 37% for CDH13, 34% for RAR-β, and 13% for HPP1. The methylation of p16 is correlated with smoking history and methylation of HPP1 was significantly more frequent in adenocarcinomas than in squamous cell carcinomas. This is the first description of aberrant methylation of the HPP1 gene in lung cancers and our data support the previous reports on methylation in NSCLCs and association with smoking.

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Copy and paste a formatted citation
Spandidos Publications style
Hanabata T, Tsukuda K, Toyooka S, Yano M, Aoe M, Nagahiro I, Sano Y, Date H and Shimizu N: DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers. Oncol Rep 12: 177-180, 2004.
APA
Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I. ... Shimizu, N. (2004). DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers. Oncology Reports, 12, 177-180. https://doi.org/10.3892/or.12.1.177
MLA
Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I., Sano, Y., Date, H., Shimizu, N."DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers". Oncology Reports 12.1 (2004): 177-180.
Chicago
Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I., Sano, Y., Date, H., Shimizu, N."DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers". Oncology Reports 12, no. 1 (2004): 177-180. https://doi.org/10.3892/or.12.1.177
Copy and paste a formatted citation
x
Spandidos Publications style
Hanabata T, Tsukuda K, Toyooka S, Yano M, Aoe M, Nagahiro I, Sano Y, Date H and Shimizu N: DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers. Oncol Rep 12: 177-180, 2004.
APA
Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I. ... Shimizu, N. (2004). DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers. Oncology Reports, 12, 177-180. https://doi.org/10.3892/or.12.1.177
MLA
Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I., Sano, Y., Date, H., Shimizu, N."DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers". Oncology Reports 12.1 (2004): 177-180.
Chicago
Hanabata, T., Tsukuda, K., Toyooka, S., Yano, M., Aoe, M., Nagahiro, I., Sano, Y., Date, H., Shimizu, N."DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers". Oncology Reports 12, no. 1 (2004): 177-180. https://doi.org/10.3892/or.12.1.177
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