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Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias

  • Authors:
    • Gennaro Chiappetta
    • Francesca Pentimalli
    • Mario Monaco
    • Monica Fedele
    • Rosa Pasquinelli
    • Giovanna Maria Pierantoni
    • Maria Teresa Ribecco
    • Giovanni Santelli
    • Daniela Califano
    • Luciano Pezzullo
    • Alfredo Fusco

  • View Affiliations

  • Published online on: August 1, 2004     https://doi.org/10.3892/or.12.2.239
  • Pages: 239-243
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Abstract

Overexpression of thymosin β-10 (TB10) has been shown in rat thyroid transformed cell lines, and in human thyroid carcinoma tissues and cell lines. To investigate whether TB10 detection could be a valid tool in the diagnosis of human thyroid neoplasias, we extended the analysis of TB10 expression to a large number of thyroid hyperproliferative and neoplastic tissues using an immunohistochemical assay. Our analyses showed a TB10 positive staining in all human thyroid carcinomas particularly in the anaplastic histotypes, whereas no TB10 immunostaining was observed in normal thyroid, in adenomas and the majority of the goiters. These results suggest that the evaluation of TB10 gene expression may be considered a promising means of diagnosis of human thyroid hyperproliferative disorders.

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August 2004
Volume 12 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 3.8
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Chiappetta G, Pentimalli F, Monaco M, Fedele M, Pasquinelli R, Pierantoni GM, Ribecco MT, Santelli G, Califano D, Pezzullo L, Pezzullo L, et al: Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. Oncol Rep 12: 239-243, 2004.
APA
Chiappetta, G., Pentimalli, F., Monaco, M., Fedele, M., Pasquinelli, R., Pierantoni, G.M. ... Fusco, A. (2004). Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. Oncology Reports, 12, 239-243. https://doi.org/10.3892/or.12.2.239
MLA
Chiappetta, G., Pentimalli, F., Monaco, M., Fedele, M., Pasquinelli, R., Pierantoni, G. M., Ribecco, M. T., Santelli, G., Califano, D., Pezzullo, L., Fusco, A."Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias". Oncology Reports 12.2 (2004): 239-243.
Chicago
Chiappetta, G., Pentimalli, F., Monaco, M., Fedele, M., Pasquinelli, R., Pierantoni, G. M., Ribecco, M. T., Santelli, G., Califano, D., Pezzullo, L., Fusco, A."Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias". Oncology Reports 12, no. 2 (2004): 239-243. https://doi.org/10.3892/or.12.2.239