No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population

  • Authors:
    • Phyu Phyu Aung
    • Shunji Matsumura
    • Kazuya Kuraoka
    • Kyoko Kunimitsu
    • Kazuhiro Yoshida
    • Keisuke Matsusaki
    • Hirofumi Nakayama
    • Wataru Yasui
  • View Affiliations

  • Published online on: November 1, 2005     https://doi.org/10.3892/or.14.5.1151
  • Pages: 1151-1154
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

DNA methylation is a major epigenetic modification in humans, and aberrant DNA methylation may play an important role in the development of various cancers through the silencing of some tumor suppressor genes. DNMT3B is required for the establishment and maintenance of genomic methylation patterns. The -149 C/T single nucleotide polymorphism (SNP) in the promoter of DNMT3B has been identified. This SNP influences DNMT3B promoter function, with the T allele having greater activity than the C allele, and is associated with an increased risk of lung cancer. The purpose of our study was to investigate the correlation between the DNMT3B promoter polymorphism and the development and progression of gastric cancer. We analyzed the SNP of the DNMT3B promoter in 152 gastric cancer patients and 247 controls from a Japanese population using PCR-RFLP and sequencing analysis, and also studied the association between the genotypes of DNMT3B and clinicopathological parameters among cases. Allelic difference was not found between gastric cancer patients and control subjects at the target site, -149 bp from the transcriptional start site in the DNMT3B gene promoter. Only the T/T genotype was detected in all gastric cancer patients and control subjects. We concluded that there was no association between SNP of the DNMT3B promoter and gastric cancer risk in a Japanese population.

Related Articles

Journal Cover

November 2005
Volume 14 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Aung PP, Matsumura S, Kuraoka K, Kunimitsu K, Yoshida K, Matsusaki K, Nakayama H and Yasui W: No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population. Oncol Rep 14: 1151-1154, 2005.
APA
Aung, P.P., Matsumura, S., Kuraoka, K., Kunimitsu, K., Yoshida, K., Matsusaki, K. ... Yasui, W. (2005). No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population. Oncology Reports, 14, 1151-1154. https://doi.org/10.3892/or.14.5.1151
MLA
Aung, P. P., Matsumura, S., Kuraoka, K., Kunimitsu, K., Yoshida, K., Matsusaki, K., Nakayama, H., Yasui, W."No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population". Oncology Reports 14.5 (2005): 1151-1154.
Chicago
Aung, P. P., Matsumura, S., Kuraoka, K., Kunimitsu, K., Yoshida, K., Matsusaki, K., Nakayama, H., Yasui, W."No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population". Oncology Reports 14, no. 5 (2005): 1151-1154. https://doi.org/10.3892/or.14.5.1151