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Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells

  • Authors:
    • Emilie Landais
    • Victoria El-Khoury
    • Alain Prevost
    • Jean Dufer
    • Françoise Liautaud-Roger

  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/or.14.6.1553
  • Pages: 1553-1558
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Abstract

Although nicotine has been implicated as a potential factor in the pathogenesis of human cancer, its mechanisms of action regarding cancer development remain largely unknown. HL-60 cells were used to investigate the effects of a short-term treatment with nicotine at concentrations found in the blood of smokers. The findings show that nicotine induces chromatin decondensation, histone H3 acetylation and up-regulation of the c-Jun transcription factor mRNA. This increase is inhibited by mecamylamine, a nicotinic receptor antagonist, suggesting that nicotine alters cellular function directly via nicotinic acetylcholine receptors and may then play a role in cell physiology and tumor promotion.

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December 2005
Volume 14 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Landais E, El-Khoury V, Prevost A, Dufer J and Liautaud-Roger F: Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells. Oncol Rep 14: 1553-1558, 2005.
APA
Landais, E., El-Khoury, V., Prevost, A., Dufer, J., & Liautaud-Roger, F. (2005). Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells. Oncology Reports, 14, 1553-1558. https://doi.org/10.3892/or.14.6.1553
MLA
Landais, E., El-Khoury, V., Prevost, A., Dufer, J., Liautaud-Roger, F."Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells". Oncology Reports 14.6 (2005): 1553-1558.
Chicago
Landais, E., El-Khoury, V., Prevost, A., Dufer, J., Liautaud-Roger, F."Nicotine induces chromatin changes and c-Jun up-regulation in HL-60 leukemia cells". Oncology Reports 14, no. 6 (2005): 1553-1558. https://doi.org/10.3892/or.14.6.1553