Increased expression of CCAAT/enhancer binding protein β correlates with prognosis in glioma patients

  • Authors:
    • Jumpei Homma
    • Ryuya Yamanaka
    • Naoki Yajima
    • Naoto Tsuchiya
    • Nobuyuki Genkai
    • Masakazu Sano
    • Ryuichi Tanaka
  • View Affiliations

  • Published online on: March 1, 2006     https://doi.org/10.3892/or.15.3.595
  • Pages: 595-601
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Abstract

C/EBP β (CCAAT/enhancer binding protein β) is a transcriptional factor that belongs to the basic region-leucine zipper class DNA-binding proteins and plays a role in cell differentiation and inflammatory reactions. Although high tissue levels of inflammatory cytokines, such as interleukin (IL)-6, IL-8 and transforming growth factor-β, have been observed in glioma patients, the mechanisms underlying this phenomenon remain to be elucidated. C/EBP β induces a variety of cytokines and thus may play a role in the pathogenesis of glioma. In this study, we investigated the relationship between C/EBP β expression, tumor histology, and prognosis in glioma. The expression of C/EBP β mRNA was examined with quantitative real-time PCR and protein expression was examined with immunohistochemical techniques in 47 glioma tissue samples. Expression of C/EBP β mRNA and protein was markedly increased in high grade glioma compared with low grade glioma. Patients whose expression of C/EBP β mRNA and protein in tumor tissue was lower survived longer than those whose expressions were higher. In vitro, C/EBP β siRNA inhibited glioma cell proliferation and invasion. Moreover, IL-8 production by glioma cells was inhibited by C/EBP β siRNA transfection. These data suggest that increased expression of C/EBP β may contribute to the promotion of tumor invasiveness and progression. The data imply that the comparison of C/EBP β expression could be a prognostic marker for patients with glioma.

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March 2006
Volume 15 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Homma J, Yamanaka R, Yajima N, Tsuchiya N, Genkai N, Sano M and Tanaka R: Increased expression of CCAAT/enhancer binding protein β correlates with prognosis in glioma patients. Oncol Rep 15: 595-601, 2006.
APA
Homma, J., Yamanaka, R., Yajima, N., Tsuchiya, N., Genkai, N., Sano, M., & Tanaka, R. (2006). Increased expression of CCAAT/enhancer binding protein β correlates with prognosis in glioma patients. Oncology Reports, 15, 595-601. https://doi.org/10.3892/or.15.3.595
MLA
Homma, J., Yamanaka, R., Yajima, N., Tsuchiya, N., Genkai, N., Sano, M., Tanaka, R."Increased expression of CCAAT/enhancer binding protein β correlates with prognosis in glioma patients". Oncology Reports 15.3 (2006): 595-601.
Chicago
Homma, J., Yamanaka, R., Yajima, N., Tsuchiya, N., Genkai, N., Sano, M., Tanaka, R."Increased expression of CCAAT/enhancer binding protein β correlates with prognosis in glioma patients". Oncology Reports 15, no. 3 (2006): 595-601. https://doi.org/10.3892/or.15.3.595