Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity

  • Authors:
    • Hideo Shigeishi
    • Koichiro Higashikawa
    • Shigehiro Ono
    • Kuniko Mizuta
    • Yoshiaki Ninomiya
    • Shingo Yoneda
    • Masayuki Taki
    • Nobuyuki Kamata
  • View Affiliations

  • Published online on: November 1, 2006     https://doi.org/10.3892/or.16.5.1071
  • Pages: 1071-1075
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We examined the expression of Centromere protein H (CENP-H) mRNA in 38 oral squamous cell carcinomas (SCCs), 2 epithelial dysplasias and 5 normal gingivae using the real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). The mean expression level of CENP-H mRNA was higher in oral SCCs (0.11±0.08) than epithelial dysplasias (0.03±0.01) and normal gingivae (0.027±0.01). The expression level of CENP-H mRNA was significantly higher in oral SCCs than normal gingivae (Mann-Whitney U test, P=0.005). We also found a significant association between the level of CENP-H mRNA expression and clinical stage in oral SCCs (Mann-Whitney U test, P=0.04). We next studied the expression of CENP-H in 17 oral SCCs immunohistochemically. A significant correlation between the expression levels of CENP-H protein and the Ki-67 labeling index was found (Mann-Whitney U test, P=0.005). These results indicate that human CENP-H is closely linked to the increased or abnormal cell proliferation in malignant conditions.

Related Articles

Journal Cover

November 2006
Volume 16 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shigeishi H, Higashikawa K, Ono S, Mizuta K, Ninomiya Y, Yoneda S, Taki M and Kamata N: Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncol Rep 16: 1071-1075, 2006.
APA
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S. ... Kamata, N. (2006). Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. Oncology Reports, 16, 1071-1075. https://doi.org/10.3892/or.16.5.1071
MLA
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N."Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity". Oncology Reports 16.5 (2006): 1071-1075.
Chicago
Shigeishi, H., Higashikawa, K., Ono, S., Mizuta, K., Ninomiya, Y., Yoneda, S., Taki, M., Kamata, N."Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity". Oncology Reports 16, no. 5 (2006): 1071-1075. https://doi.org/10.3892/or.16.5.1071