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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2007 Volume 17 Issue 4

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Article

Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma

  • Authors:
    • Osamu Takahashi
    • Jun-ichi Hamada
    • Motoki Abe
    • Shinya Hata
    • Toshimichi Asano
    • Yoko Takahashi
    • Mitsuhiro Tada
    • Masaki Miyamoto
    • Satoshi Kondo
    • Tetsuya Moriuchi

  • View Affiliations / Copyright

    Affiliations: Division of Cancer-Related Genes, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan
  • Pages: 753-760
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.753
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Abstract

Homeobox genes function as master regulators in embryonic morphogenesis. We hypothesized that homeobox genes are essential to maintain tissue- or organ-specificity even in adult body and that the dysregulated expression of homeobox genes results in tumor development and progression. To better understand the roles of homeobox genes in development and progression of esophageal cancer, we analyzed the expression patterns of 39 HOX genes and 4 ParaHOX (CDX1, CDX2, CDX4 and PDX1) genes in esophageal squamous cell carcinoma (ESCC) and normal esophageal mucosa tissues. A total of 48 primary ESCC tissues and 7 normal esophageal mucosa tissues were resected from patients who underwent radical surgery without any preoperative chemotherapy or radiotherapy. The expression of HOX and ParaHOX genes were analyzed by a quantitative real-time RT-PCR method and immunohistochemistry. The expression levels of 24 HOX genes, CDX1, CDX2 and PDX1 were significantly higher in ESCC compared to normal mucosa (p<0.01, Mann-Whitney U test). The Immunohistochemical study revealed that HOXA5 and D9 proteins were more cytoplasmic in ESCC than normal mucosa cells. Our data indicate that the disordered expression of HOX and ParaHOX genes are involved in the development of ESCC or its malignancy.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi O, Hamada J, Abe M, Hata S, Asano T, Takahashi Y, Tada M, Miyamoto M, Kondo S, Moriuchi T, Moriuchi T, et al: Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma. Oncol Rep 17: 753-760, 2007.
APA
Takahashi, O., Hamada, J., Abe, M., Hata, S., Asano, T., Takahashi, Y. ... Moriuchi, T. (2007). Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma. Oncology Reports, 17, 753-760. https://doi.org/10.3892/or.17.4.753
MLA
Takahashi, O., Hamada, J., Abe, M., Hata, S., Asano, T., Takahashi, Y., Tada, M., Miyamoto, M., Kondo, S., Moriuchi, T."Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma". Oncology Reports 17.4 (2007): 753-760.
Chicago
Takahashi, O., Hamada, J., Abe, M., Hata, S., Asano, T., Takahashi, Y., Tada, M., Miyamoto, M., Kondo, S., Moriuchi, T."Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma". Oncology Reports 17, no. 4 (2007): 753-760. https://doi.org/10.3892/or.17.4.753
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi O, Hamada J, Abe M, Hata S, Asano T, Takahashi Y, Tada M, Miyamoto M, Kondo S, Moriuchi T, Moriuchi T, et al: Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma. Oncol Rep 17: 753-760, 2007.
APA
Takahashi, O., Hamada, J., Abe, M., Hata, S., Asano, T., Takahashi, Y. ... Moriuchi, T. (2007). Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma. Oncology Reports, 17, 753-760. https://doi.org/10.3892/or.17.4.753
MLA
Takahashi, O., Hamada, J., Abe, M., Hata, S., Asano, T., Takahashi, Y., Tada, M., Miyamoto, M., Kondo, S., Moriuchi, T."Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma". Oncology Reports 17.4 (2007): 753-760.
Chicago
Takahashi, O., Hamada, J., Abe, M., Hata, S., Asano, T., Takahashi, Y., Tada, M., Miyamoto, M., Kondo, S., Moriuchi, T."Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma". Oncology Reports 17, no. 4 (2007): 753-760. https://doi.org/10.3892/or.17.4.753
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