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Effects of the PPARγ agonist GW1929 on muscle wasting in tumour-bearing mice

  • Authors:
    • Rodrigo Moore-Carrasco
    • Maite Figueras
    • Elisabet Ametller
    • Francisco J. López-Soriano
    • Josep M. Argilés
    • Sílvia Busquets

  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/or.19.1.253
  • Pages: 253-256
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Abstract

Administration of the PPARγ agonist GW1929 (10 mg/kg body weight) results in amelioration of muscle loss in tumour-bearing mice experimental cachexia. The effect of the agonist, which seems to be specific for white muscle extensor digitorum longus (EDL), is accompanied by an increase in the levels of the transcription factor MyoD and also the GLUT-4 glucose transporter. In addition, the effects of GW1929 on skeletal muscle are direct since incubation of isolated rat skeletal muscles in its presence results in a decreased rate of protein degradation. Collectively, the results presented suggest a potential clinical application - possibly in combination with other anabolic strategies - of GW1929 in restoring muscle waste during cancer cachexia.

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Journal Cover

January 2008
Volume 19 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
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  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Moore-Carrasco R, Figueras M, Ametller E, López-Soriano FJ, Argilés JM and Busquets S: Effects of the PPARγ agonist GW1929 on muscle wasting in tumour-bearing mice. Oncol Rep 19: 253-256, 2008.
APA
Moore-Carrasco, R., Figueras, M., Ametller, E., López-Soriano, F.J., Argilés, J.M., & Busquets, S. (2008). Effects of the PPARγ agonist GW1929 on muscle wasting in tumour-bearing mice. Oncology Reports, 19, 253-256. https://doi.org/10.3892/or.19.1.253
MLA
Moore-Carrasco, R., Figueras, M., Ametller, E., López-Soriano, F. J., Argilés, J. M., Busquets, S."Effects of the PPARγ agonist GW1929 on muscle wasting in tumour-bearing mice". Oncology Reports 19.1 (2008): 253-256.
Chicago
Moore-Carrasco, R., Figueras, M., Ametller, E., López-Soriano, F. J., Argilés, J. M., Busquets, S."Effects of the PPARγ agonist GW1929 on muscle wasting in tumour-bearing mice". Oncology Reports 19, no. 1 (2008): 253-256. https://doi.org/10.3892/or.19.1.253