Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: Implications for tumor cell differentiation

  • Authors:
    • Yutaka Doi
    • Hitoshi Kawamata
    • Yuko Ono
    • Takahiro Fujimori
    • Yutaka Imai
  • View Affiliations

  • Published online on: March 1, 2008     https://doi.org/10.3892/or.19.3.609
  • Pages: 609-616
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Abstract

TGF-β-stimulated clone-22 (TSC-22) was reported to be a differentiation-inducing factor which negatively regulates the growth of salivary gland cancer cells. In the present study, we examined the expression of TSC-22 in salivary gland tumors by immunohistochemistry. In pleomorphic adenoma (PA), most of the sparse myoepithelial-like tumor cells, which are considered as the differentiated cells because they produce extracellular matrix, expressed TSC-22. However, only a limited number of cases of the solid myoepithelial-like tumor cells in PA, which are considered as the growing cells, expressed TSC-22. In adenoid cystic carcinoma (ACC), inner ductal cells in the tubular structure, strongly expressed TSC-22, though the outer myoepithelial-like tumor cells did not express TSC-22. In the cribriform structure, myoepithelial-like tumor cells did not express TSC-22. However, a small ductal structure in the micro-cyst wall strongly expressed TSC-22. Sparse type myoepithelial-like tumor cells in ACC also expressed TSC-22. In mucoepidermoid carcinoma, epidermoid tumor cells and mucous-producing tumor cells in mucoepidermoid carcinoma frequently expressed TSC-22. Thus, the expression of TSC-22 was frequently observed in the cells with differentiated-phenotypes, although rarely in the cells with growing potentials. These results suggest that TSC-22 may play an important role in maintaining the differentiated phenotype in salivary gland tumors.

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March 2008
Volume 19 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Doi Y, Kawamata H, Ono Y, Fujimori T and Imai Y: Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: Implications for tumor cell differentiation. Oncol Rep 19: 609-616, 2008.
APA
Doi, Y., Kawamata, H., Ono, Y., Fujimori, T., & Imai, Y. (2008). Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: Implications for tumor cell differentiation. Oncology Reports, 19, 609-616. https://doi.org/10.3892/or.19.3.609
MLA
Doi, Y., Kawamata, H., Ono, Y., Fujimori, T., Imai, Y."Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: Implications for tumor cell differentiation". Oncology Reports 19.3 (2008): 609-616.
Chicago
Doi, Y., Kawamata, H., Ono, Y., Fujimori, T., Imai, Y."Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: Implications for tumor cell differentiation". Oncology Reports 19, no. 3 (2008): 609-616. https://doi.org/10.3892/or.19.3.609