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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2008 Volume 19 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas

  • Authors:
    • Kennichi Satoh
    • Atsushi Kanno
    • Shin Hamada
    • Morihisa Hirota
    • Jun Umino
    • Atsushi Masamune
    • Shinichi Egawa
    • Fuyuhiko Motoi
    • Michiaki Unno
    • Tooru Shimosegawa

  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan. ksatoh@mail.tains.tohoku.ac.jp
  • Pages: 1185-1190
    |
    Published online on: May 1, 2008
       https://doi.org/10.3892/or.19.5.1185
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Abstract

Sonic hedgehog (SHH) is frequently expressed in pre-cancerous lesions and carcinoma of the pancreas. A recent study revealed that its expression was higher in the intraductal papillary mucinous neoplasm (IPMN) of the pancreas than in the pancreatic carcinoma. However, the correlation between its signaling pathway and tumorigenesis of IPMN has not yet been well documented. We investigated the expression of mRNA and protein of SHH as well as its downstream transcription factor Gli1 in 19 microdissected lesions from 15 cases and in 75 lesions from 33 cases of the IPMN by one-step quantitative real-time reverse transcription-polymerase chain reaction and immunohistochemistry, respectively. SHH and Gli1 mRNAs were detected in all the examined lesions and 8 out of 19 lesions in IPMNs, respectively. SHH and Gli1 mRNAs were likely to be up-regulated from the adenoma and from borderline to carcinoma cells, respectively. Immunohistochemical analysis also reported that SHH and Gli1 expression was correlated with the grade of cell atypia. These findings suggested that HH signaling was activated in IPMNs and contributed to tumorigenesis in these types of neoplasms.

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Copy and paste a formatted citation
Spandidos Publications style
Satoh K, Kanno A, Hamada S, Hirota M, Umino J, Masamune A, Egawa S, Motoi F, Unno M, Shimosegawa T, Shimosegawa T, et al: Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas. Oncol Rep 19: 1185-1190, 2008.
APA
Satoh, K., Kanno, A., Hamada, S., Hirota, M., Umino, J., Masamune, A. ... Shimosegawa, T. (2008). Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas. Oncology Reports, 19, 1185-1190. https://doi.org/10.3892/or.19.5.1185
MLA
Satoh, K., Kanno, A., Hamada, S., Hirota, M., Umino, J., Masamune, A., Egawa, S., Motoi, F., Unno, M., Shimosegawa, T."Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas". Oncology Reports 19.5 (2008): 1185-1190.
Chicago
Satoh, K., Kanno, A., Hamada, S., Hirota, M., Umino, J., Masamune, A., Egawa, S., Motoi, F., Unno, M., Shimosegawa, T."Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas". Oncology Reports 19, no. 5 (2008): 1185-1190. https://doi.org/10.3892/or.19.5.1185
Copy and paste a formatted citation
x
Spandidos Publications style
Satoh K, Kanno A, Hamada S, Hirota M, Umino J, Masamune A, Egawa S, Motoi F, Unno M, Shimosegawa T, Shimosegawa T, et al: Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas. Oncol Rep 19: 1185-1190, 2008.
APA
Satoh, K., Kanno, A., Hamada, S., Hirota, M., Umino, J., Masamune, A. ... Shimosegawa, T. (2008). Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas. Oncology Reports, 19, 1185-1190. https://doi.org/10.3892/or.19.5.1185
MLA
Satoh, K., Kanno, A., Hamada, S., Hirota, M., Umino, J., Masamune, A., Egawa, S., Motoi, F., Unno, M., Shimosegawa, T."Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas". Oncology Reports 19.5 (2008): 1185-1190.
Chicago
Satoh, K., Kanno, A., Hamada, S., Hirota, M., Umino, J., Masamune, A., Egawa, S., Motoi, F., Unno, M., Shimosegawa, T."Expression of Sonic hedgehog signaling pathway correlates with the tumorigenesis of intraductal papillary mucinous neoplasm of the pancreas". Oncology Reports 19, no. 5 (2008): 1185-1190. https://doi.org/10.3892/or.19.5.1185
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