IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN AND PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) IN SALIVARY-GLAND TUMORS
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- Published online on: March 1, 1995 https://doi.org/10.3892/or.2.2.233
- Pages: 233-236
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Abstract
The expression of p53 protein and PCNA was immunohistochemically examined in 161 cases of salivary gland tumors. The p53 protein was positive in 23.8% (24/101) of malignant salivary gland tumors, while only one case of 60 pleomorphic adenomas was positive. p53 protein was frequently detectable in salivary duct carcinoma (60%), basal cell adenocarcinoma (66.7%), acinic cell carcinoma (53.3%) and undifferentiated carcinoma (50%), but was rarely seen in adenoid cystic carcinoma (17.2%) and mucoepidermoid carcinoma (0%). p53 protein was more frequently detectable in PCNA positive cases than in negative cases (p=0.0074).