ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES
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- Published online on: March 1, 1995 https://doi.org/10.3892/or.2.2.277
- Pages: 277-280
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Abstract
The association between gene alterations (K-ras, p53, N-myc) and drug resistance (CDDP, CBDCA, MMC, Epi-ADM) was examined in 29 human lung carcinoma cell lines using the in vitro MTT assay. There was no significant difference in the IC50 values of four drugs between K-ras or p53 gene alteration-positive and -negative groups. However, two cell lines with N-myc amplification showed a higher resistance than those without N-myc amplification to all four drugs. This preliminary study suggests that K-ras or p53 gene alteration is probably not related to drug resistance, but N-myc might be.
