GONADOTROPIN-RELEASING-HORMONE (GN-RH) RECEPTOR IN THE REPRODUCTIVE-TRACT TUMOR - PHYSIOLOGICAL-ROLE AND SIGNAL-TRANSDUCTION PATHWAY
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- Published online on: July 1, 1995 https://doi.org/10.3892/or.2.4.625
- Pages: 625-631
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Abstract
Gonadotropin-releasing hormoen (Gn-RH) analogs have been used in the therapy of the endocrine-dependent cancers including the repductive tract-originated tumors. Gn-RH receptor and its transmembrane signaling pathways have been demonstrated in a high proportion of these tumors. The demonstration of existence of receptors for a hormone can better predict hormonal dependency, and might be a first step towards an effective hormonal treatment. These findings suggest the merit of further therapeutic investigations of Gn-RH analogs alone or in combination with traditional therapies in the management of Gn-RH receptor-positive tumors.