The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells

  • Authors:
    • Ya-Dong Zheng
    • Xi-Qiang Xu
    • Fei Peng
    • Ji-Zhe Yu
    • Hua Wu
  • View Affiliations

  • Published online on: March 10, 2011     https://doi.org/10.3892/or.2011.1212
  • Pages: 1399-1405
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pharmacological inhibition of DNA repair pathways has been emerging as an effective tool for cancer treatment. Poly(ADP-ribose) polymerase (PARP) is involved in DNA repair and transcriptional regulation and is now recognized as a key regulator of cell survival and cell death. In vitro and in vivo data suggest that PARP inhibitors could be used not only as chemo/radiotherapy sensitizers but also as single agents to selectively kill cancer cells in certain types of tumors. In the present study, we investigate the effects of 3-aminobenzamide (3-AB), a potent inhibitor of PARP, on human osteosarcoma cells and whether or not it can sensitize the tumor cells to chemotherapeutic agents. The results indicated that 3-AB suppressed U2OS cell growth in a time- and dose-dependent manner, and the suppressive effects of 3-AB were associated with increased cell apoptosis. In addition, 3-AB suppressed cell invasion in vitro and enhanced the suppressive effects of cisplatin in U2OS cells. Our work suggests that this PARP-1 inhibitor may be developed into an effective agent for the treatment of human osteosarcoma.

Related Articles

Journal Cover

May 2011
Volume 25 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Y, Xu X, Peng F, Yu J and Wu H: The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells. Oncol Rep 25: 1399-1405, 2011.
APA
Zheng, Y., Xu, X., Peng, F., Yu, J., & Wu, H. (2011). The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells. Oncology Reports, 25, 1399-1405. https://doi.org/10.3892/or.2011.1212
MLA
Zheng, Y., Xu, X., Peng, F., Yu, J., Wu, H."The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells". Oncology Reports 25.5 (2011): 1399-1405.
Chicago
Zheng, Y., Xu, X., Peng, F., Yu, J., Wu, H."The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells". Oncology Reports 25, no. 5 (2011): 1399-1405. https://doi.org/10.3892/or.2011.1212